Final Four Odds for March Madness – Odds to Reach Final Four for All 68 Teams in 2025 NCAA Tournament

• The 2025 March Madness bracket is set and odds are out to win each region
• All four #1 seeds are the betting favorites to win their respective regions
• Below, see the opening Final Four odds for all 68 teams in the 2025 NCAA Tournament

The 2025 NCAA Tournament field has been set (and you can download SBD’s printable March Madness bracket here). Sportsbooks were quick to release odds to win each of the four regions, which is the same as saying odds to reach the 2025 Final Four. Below, find the opening odds for all four regions. Spoiler alert: the #1 seed is the chalk in all four.

Jump to: East Region / Midwest Region / South Region / West Region

Odds to Win East Region

Odds as of March 16 at DraftKings.

Once it was announced that Cooper Flagg would return from the ankle injury he suffered in the quarterfinals of the ACC Tournament in time for March Madness, it was a foregone conclusion, not only that Duke would be a #1 seed, but also that they would be the heavy chalk to win it. Duke has the best Final Four odds of any team in the 2025 NCAA Tournament at -115. Only one other team (West #1 Florida) is shorter than even-money. Duke is also the outright favorite in the March Madness championship odds at +350.

Duke is the top team in all the polls and rates as the top team at KenPom, Haslametrics, and Torvik. And it’s not particularly close. At KenPom, Duke’s +38.16 rating is a full two points higher than #2 Florida (+36.16).

The East Region odds are chalky even after Duke. The top-four seeds are also the top-four favorites: #2 Alabama (+475), #3 Wisconsin (+900), and #4 Arizona (+950).

Odds to Win Midwest Region

Odds as of March 16 at FanDuel.

The Midwest Region odds see Houston as a firm +155 favorite to advance to the Final Four. The Cougars rate third in Net Rating at KenPom and are coming off an absolutely dominant Big 12 season. They went 19-1 in conference play and won their three Big 12 Tournament games by eight or more points.

The second-seeded Tennessee Volunteers are the second-favorite at +340, but after that it gets interesting. The Gonzaga Bulldogs, the #8 seed which will meet Houston in the round of 32 if they beat #9 Georgia, is tied for the third-best odds at +850, alongside #3 Kentucky and #6 Illinois.

Gonzaga is on a run of nine straight Sweet 16 appearances, the longest active streak in the country. Only two teams in history have longer streaks, and neither of those took place exclusively in the 64-team era.

Odds to Win South Region

Odds as of March 16 at FanDuel.

In the South Region, a somewhat-slumping #1 Auburn is the +110 favorite, well ahead of second-favorite #2 Michigan State at +470 and third-favorite #3 Iowa State.

Then there’s an even bigger drop to the rest of the field, starting with #4 Texas A&M at a long +1200.

Curiously, #11 North Carolina, who many think shouldn’t even be in the field and have to go through the First Four, are at +4500, ahead of #10 New Mexico (+6500) an #12 San Diego State (+500), and way ahead of the team they’re facing in the First Four: San Diego State (+24000).

The first-round March Madness odds show North Carolina favored by 3.5 points over the Aztecs in Tuesday’s First Four game in Dayton. The Tar Heels are -192 on the moneyline.

Odds to Win West Region

Odds as of March 16 at FanDuel.

The West Region contains the only other odds-on Final Four favorite, the red-hot Florida Gators, who just blitzed their three opponents in the SEC Tournament to grab the fourth and final #1 seed. The Gators are -110 to come out of the West, with second-favorite #3 Texas Tech well back at +470.

The #2 St John’s Red Storm are the third-favorite at +600.

The West is the one region where a double-digit seed is favored in its first round matchup; the #12 Colorado State Rams are favored by 3.5 over the #5 Memphis Tigers, and that shows in their respective Final Four odds. The Rams are +6500 to reach the Final Four, while the Tigers are +9000.