NFL Wild Card Weekend Odds – Opening Betting Lines & Spread for All Games

• The NFL wild-card playoff round is set to begin Saturday, Jan. 14,  and continue through Monday, Jan. 16
• The Bills are the biggest favorites at 10 points over the Dolphins
• A look at the opening NFL wild-card round odds can be found below

The Buffalo Bills have opened as the biggest favorites in the wild-card round of the NFL playoffs by 10 points over the visiting Miami Dolphins in the AFC at 1:05 p.m. ET Sunday.

The Bills have a 13-3 record. The Dolphins are 9-8.

In the other AFC games, the Cincinnati Bengals (12-4) are favored by 5.5 points at home over the Baltimore Ravens (10-7) at 8:15 p.m. ET Sunday and the Los Angeles Chargers (10-7) are 2.5-point road picks over the Jacksonville Jaguars (9-8) at 8:15 p.m. ET Saturday.

In the NFC, the Dallas Cowboys (12-5) are three-point road favorites over the Tampa Bay Buccaneers (8-9) at 8:15 p.m. ET Monday and the Minnesota Vikings (13-4) are favored by three points over the New York Giants (9-7-1) at 4:40 p.m. ET Sunday.

The third NFC matchup has the San Francisco 49ers (13-4) favored by 6.5 points over the visiting Seattle Seahawks (9-8) at 4:35 p.m. ET Saturday.

NFL Wild-Card Playoff Opening Odds

Odds as of January 8th at DraftKings. Claim the DraftKings Sportsbook promo code. 

Ravens vs Bengals Early Odds & Prediction

This will be a rematch of Sunday’s season finale, which was also played in Cincinnati and won by the Bengals 27-16. The AFC North rivals split their season series as the Ravens won 19-17 on Oct. 9 at home.

On Sunday, Joe Burrow threw a touchdown and Joe Mixon ran for a TD to lead the Bengals.

Mixon really had a coin in his glove 😂#BudLightCelly | @budlight pic.twitter.com/eg8evfvtsT

— Cincinnati Bengals (@Bengals) January 8, 2023

The Bengals won their last eight regular season games. The Ravens enter the postseason off back-to-back losses and the status of quarterback Lamar Jackson (knee) being uncertain.

It’s hard to buck the Bengals, even if Jackson returns as he would likely be rusty after missing five games in a row.

Pick: Bengals -5.5 (-110)

Jaguars vs Chargers Early Odds & Prediction

The Chargers rolled to a 38-10 victory over the Jaguars on Sept. 25 at home.

However, the Jaguars are on a five-game winning streak, including beating the visiting Tennessee Titans 20-16 on Saturday night in a showdown for the AFC South title. The Chargers lost to the Broncos 31-28 on Sunday in Denver, ending their four-game winning streak.

The Chargers’ four-touchdown win over Jacksonville was more than three months ago. The Jaguars are a much better team now and good enough to knock off Los Angeles as home underdogs.

Pick: Jaguars +112 ML

Dolphins vs Bills Early Odds & Prediction

The AFC East rivals split their regular-season series with each team winning at home. The Dolphins notched a 21-19 victory on Sept. 25 and the Bills won 32-29 on Dec. 17.

At home for the third matchup, the Bills are riding a seven-game winning streak after beating the visiting New England Patriots 35-23 on Sunday. Nyheim Hines returned two kickoffs for touchdowns in an emotionally charged game six days after Bills safety Damar Hamlin suffered cardiac arrest during a game in Cincinnati.

The Dolphins ended a four-game losing streak by getting past the New York Jets 11-6. Jason Sanders kicked a go-ahead 50-yard field goal with 18 seconds left.

The number is big but it’s hard to bet against the Bills in Orchard Park in January.

Pick: Bills -10 (-110)

Cowboys vs Buccaneers Early Odds & Prediction

These teams also met in Tampa to begin the season and the Buccaneers won 19-3 on Sept. 11.

Both teams finished the regular season with road losses on Sunday. The Cowboys were thumped by the Washington Commanders 26-6 and the Buccaneers were beaten by the Atlanta Falcons 30-17.

Even with Tom Brady, it’s hard to get behind the 8-9 Buccaneers. Look for the Cowboys to win and cover on the road.

Pick: Cowboys -3 (-110)

Giants vs Vikings Early Odds & Prediction

These teams meet again in Minneapolis after the Vikings eked out a 27-24 victory on Christmas Eve.

The Vikings have won three of their last four games, including beating the Bears 29-13 on Sunday in Chicago. Kirk Cousins threw for 225 yards and a touchdown while playing only the first half for Minnesota.

.@athielen19 red zone TD 🙌

📺: @NFLonFOX pic.twitter.com/A3QaiNW08r

— Minnesota Vikings (@Vikings) January 8, 2023

The Giants lost for the third time in their last five games, 22-16 to the Eagles in Philadelphia.

The Vikings won 13 games in the regular season despite being outscored by three points. That luck will run out in the playoffs.

Pick: Giants +126 ML

Seahawks vs 49ers Early Odds & Prediction

The 49ers beat the Seahawks twice in the regular season, 27-7 on Sept. 18 at home and 21-13 on Dec. 15 in Seattle.

San Francisco will bring a 10-game winning streak into this game in Santa Clara after dispatching the Arizona Cardinals 38-13 on Sunday. Rookie Brock Purdy threw three touchdown passes, giving him six consecutive games with multiple TD passes.

The Seahawks beat the Rams 19-16 on Jason Myers’ 32-yard field goal in overtime and then got the last playoff berth when the Green Bay Packers were upset at home by the Detroit Lions 20-16 on Sunday night. Seattle has won consecutive games following a three-game losing streak.

The Seahawks have done well to make the playoffs in their first season after trading quarterback Russell Wilson but are no match for the 49ers.

Pick: 49ers -6.5 (-110