NFL Week 18 Odds – Opening Betting Lines & Spreads for All Games

• NFL Week 18 begins Saturday with the Chiefs visiting the Raiders and the Jaguars hosting the Titans
• The biggest NFL Week 18 opening favorite is the 49ers by 13.5 points over the Cardinals
• A look at all the NFL Week 18 opening odds can be found below with early picks

NFL Week 18, which ends the regular season, begins with a doubleheader Saturday.

The Kansas City Chiefs visit the Las Vegas Raiders at 4:30 pm ET. The Jacksonville Jaguars then play host to the Tennessee Titans at 8 pm ET.

The remainder of the 16-game slate will be played Sunday with three playoff spots to be determined – two in the AFC and one in the NFC.

NFL Week 18 Opening Odds

Odds as of January 1st at FanDuel

The San Francisco 49ers are the week’s biggest favorites by 13.5 points over the Arizona Cardinals in the NFL odds. The smallest favorites are the Pittsburgh Steelers by two points over the Cleveland Browns.

Chiefs vs Raiders has the highest over/under at 49.5 points. The lowest total is 38 for Tampa Bay Buccaneers vs Atlanta Falcons.

DRAFTKINGS
SPORTSBOOK

Bet $5 & Get $200 in Bonus Bets + $50 Deposit Bonus

LOCK IN PROMO

SIGNUP PROMO

BET $5
GET $250

GET PROMO

Titans vs Jaguars Early Odds & Prediction

The AFC South title will go to the winner when the Tennessee Titans (7-9) visit the Jacksonville Jaguars (8-8) at TIAA Bank Stadium. The Jaguars are favored by 5.5 points.

The Titans are on a six-game losing streak, the latest defeat coming on Thursday night to the Dallas Cowboys 27-13. The Jaguars routed the Texans 31-3 on Sunday on the road to run their winning streak to four games.

Travis Etienne ran for 108 yards and a touchdown in the first half to lead the Jaguars then was rested for the final two quarters. Jacksonville also got a fumble return by Tyson Campbell for a score.

.@swaggy_t1 with the H-Town house call!#JAXvsHOU on CBS/NFL+ pic.twitter.com/m5mNUuULJe

— Jacksonville Jaguars (@Jaguars) January 1, 2023

Trevor Lawrence played just one possession in the third quarter and finished with 152 yards passing. The Jaguars led 28-3 at halftime.

Journeyman quarterback Joshua Dobbs made his first career start ahead of rookie Malik Willis for the Titans on Thursday. Dobbs threw for 232 yards and a TD with one interception.

The Titans are banged up and beaten down. The streaking Jaguars will win this one going away.

Pick: Jaguars -5.5 (-110)

Lions vs Packers Early Odds & Prediction

This is basically a playoff game as the Green Bay Packers (8-8) host the Detroit Lions (8-8) at Lambeau Field as 4.5-point favorites. The Packers make the playoffs with a win. The Lions need to both win and have the Seattle Seahawks lose to the Los Angeles Raiders to quality for the postseason.

The Lions won for the fourth time in their last five games when they blasted the Chicago Bears 41-10 on Sunday. The Packers extended their winning streak to four games by drubbing the NFC North champion Minnesota Vikings 41-17.

Jared Goff threw three touchdown passes for the Lions, including two to Brock Wright in the first half. That kept Detroit’s hopes alive of reaching the playoffs for the first time since 2016.

Goff completed passes to 10 different receivers as he went 21 of 29 for 255 yards. He also did not throw an interception for an eighth straight game.

Starting 2023 off Wright!#CHIvsDET | 📺 FOX pic.twitter.com/XJ7kJbzWQb

— Detroit Lions (@Lions) January 1, 2023

Aaron Rodgers threw a TD pass and ran for a score to lead the Packers, who also got two touchdowns on long returns. Keisean Nixon ran a kickoff back 105 yards and Darnell Savage had a 75-yard pick-six.

Aaron Jones rushed for 111 yards on 14 carries.

These aren’t the same old Lions as coach Dan Campbell is changing the organization’s culture. Detroit might not make the playoffs, but it won’t lay an egg in a pivotal game.

Pick: Lions +4.5 (-114)

Buccaneers vs Falcons Early Odds & Prediction

The Tampa Bay Buccaneers are seven-point underdogs to the Atlanta Falcons on the road despite clinching the NFC South title on Sunday. The Falcons are such big favorites because the Buccaneers plan to rest quarterback Tom Brady for the playoffs.

The Buccaneers are still better than the Falcons even without Brady. It’s also difficult to see the Falcons favored by a touchdown against any opponent with rookie Desmond Ridder at QB.

Look for this line to get bet down.

Pick: Buccaneers +7 (-110)