San Francisco 49ers vs Seattle Seahawks Predictions, Picks & Best Odds for TNF (Week 6)

• The 2-3 San Francisco 49ers visit the 3-2 Seattle Seahawks in an important NFC West clash on TNF
• The Seahawks have lost to straight after a 3-0 start while the Niners have dropped two of three to fall under .500
• See the 49ers vs Seahawks picks, predictions, and best available odds for Thursday Night Football

Two NFC West teams mired in slumps will meet on Thursday Night Football in Week 6 as the Seattle Seahawks (3-2, 2-1 home, 1-3-1 ATS) host the San Francisco 49ers (2-3, 0-2 away, 2-3 ATS) at Lumen Field at 5:15 pm PT/8:15 pm ET. Still without Christian McCaffrey and battling a rash of other injuries, the 49ers head into Seattle as 3.5-point road favorites in the current football betting lines.

San Francisco 49ers vs Seattle Seahawks Predictions & Picks

• Seahawks +3.5 (-105) at Caesars
• Over 48.5 (-115) at FanDuel

Sascha Paruk’s 2024 NFL picks: 13-15 (-1.17 units)

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Coming off by far their most disappointing performance of the season – a 29-20 loss at home to the Giants as 7.5-point favorites – the Seahawks now find themselves catching more than a field goal against the banged-up 49ers, who suffered their own devastating setback in Week 5 when they fell 24-23 to the Cardinals also as 7.5-point home chalk. San Francisco was shutout in the entire second half, blowing a 23-10 lead at the break.

In addition to McCaffrey, the Niners have a litany of injuries on the defensive side of the ball. Five starters are either out or questionable on a short week: Charvarius Ward (questionable, knee), Demetrius Flannigan-Fowles (questionable, calf), Ji’Ayir Brown (questionable, ankle), Jordan Elliott (questionable, knee), and safety Talanoa Hufanga (out, wrist).

Tight end George Kittle is also questionable with a rib injury.

George Kittle, Fred Warner remain limited on Tuesday’s estimated injury report. https://t.co/vO1yBGsNEx

— ProFootballTalk (@ProFootballTalk) October 9, 2024

The Seahawks injury situation isn’t nearly as dire. No one of any significance on the offense has an injury designation (though OT George Fant remains on IR). On defense, linebacker Derick Hall (foot), cornerback Riq Woolen (ankle), and free safety Julian Love (hamstring) are all questionable.

The 49ers have won four straight against the Seahawks, including two in a row in Seattle, and all four games were fairly lopsided. The smallest margin of victory was eight points and the average was 14.5. But I’ve seen enough over the last four weeks to downgrade the Niners pretty significantly. Their shorthanded defense isn’t dominating the way it used to, and the offense isn’t the same without McCaffrey.

Heading into Week 6, the Seahawks actually rank higher than the Niners in DVOA (8th vs 9th). Purdy and his talented group of pass catchers will still put up some points, which is why I’m also taking the over, but I love the Seahawks catching a field goal plus the hook at home.

Best Available 49ers vs Seahawks Odds

There is a very little variation in the spread across different sportsbooks. Every book currently has the line at 49ers -3.5 (up half a point from the opening odds, which were 49ers -3). The only difference is a slight discrepancy the odds. BetMGM currently lists San Fran -3.5 at -105 odds, which is the longest bettors will find. Caesars Sportsbook has the longest price on Seattle +3.5, which is also -105.

There are bigger differences with respect to the moneyline and the total. The best moneyline price for a Seattle SU victory is +158 at Caesars. (It’s as short as +142 at FanDuel.) The longest odds on the Niners to win straight-up are -176 at FanDuel.

There is also a full point difference in the game total with ESPN Bet listing it at 49.5 (O -115/U -105) and FanDuel listing it at 48.5 (O -105/U -115).