San Francisco 49ers vs Chicago Bears Odds, Betting Lines, and Picks for Week 1 of NFL Season

• Can the Bears surprise most experts and upend the 49ers when the two clubs open the NFL season on Sunday, September 11?
• The Bears are 0-6 against the spread in their last six games as a home underdog. San Francisco is 5-2 SU and ATS in their last seven games as a favorite.
• Read on for the odds and our best 49ers vs Bears picks below

San Francisco has playoff aspirations once again while Chicago tries to get back to respectability.

The 49ers did make noise in last year’s playoffs beating Dallas. They are eighth currently (+1600) in the Super Bowl odds this season.

The 49ers are also being set as 7.0-point road favorites over the Bears in the season opener for both teams. San Francisco is 5-0 against the spread over the past five games.

49ers vs Bears NFL Week 1 Odds

Odds as of September 9 at Caesars Sportsbook. See the available Caesars Sportsbook promo code for the NFL here.

The 49ers are listed as heavy favorites in this on at -305 on the moneyline and as 7-point chalk on the spread. The total is set at 40.5.

Kickoff at Soldier Field is set for 1:00 pm ET. The weather forecast is calling for some rain, 12-18 mph winds and a temperature of 60 degrees. FOX is carrying the broadcast, but it can also be streamed via fuboTV. In Canada, the action is available through TSN and DAZN.

49ers and Bears NFL Betting Trends

In order to beat the 49ers, the Chicago Bears are going to have to do something they have not done lately — win at home. Chicago went just 3-5 at Soldier Field last year and after two early wins that lone victory came against the lowly New York Giants. Things get worse for the Bears when one considers they lost to these same 49ers 33-22 last year despite holding the ball for nearly 37 minutes.

Some @ChicagoBears ATS info from @SOHistory. In 2021 they were 3-0 ATS at home as favorites but 1-4 ATS as home underdogs. They were 7-10 ATS overall. Interactive chart here https://t.co/uRCoPLzfDI #BearDown @CarmenDeFalco pic.twitter.com/E3j6a70jra

— Bob Downtown (@ChiBearsNerd) September 4, 2022

San Francisco has its own betting trends to draw upon. The 49ers are oddly 1-4 ATS in their last five season openers but that may be the only negative here. The Under, even around 40.5 is favorable potentially. That has connected in the previous four San Francisco games played on grass. Obviously, Soldier Field on a chilly, wet track favors less scoring and sloppier ball-handling conditions.

In NFL public betting trends, people are on board with San Francisco. Spread wagering is showing 64% of handle and 61% of bets are on the 49ers. In moneyline wagering, 88% of bets are backing San Francisco. The over is getting the action on the total. There’s 62% of handle and 54% of bets supporting the teams going over 40.5 points. However, again watch the weather conditions as they could change between now and Sunday.

49ers TE Kittle Likely Out With Groin Injury

49ers TE George Kittle is likely out Sunday due to a Grade 2 groin injury. The team had not said much about it until Wednesday or so. Right now, the expectation is that the All-Pro Tight End will sit out Week 1 and that will be one less weapon Chicago has to worry about.

The 49ers are entering the NFL season a little banged up. Hamstring injuries have claimed several players with knee injuries causing several others to be probable. Kittle remains the significant loss.

From yesterday:#49ers-Bears Injury Report: George Kittle misses another practicehttps://t.co/Az9JZI4fTg

— 49ers Webzone (@49erswebzone) September 9, 2022

Kittle may play but could miss a few weeks as well. Do not expect much of him Sunday either way. The Bears are a bit healthier but watch the status of DE Dominique Robinson (knee) and WR Velus Jones (hamstring).

Will the Ground Games Reign Supreme?

Caesars Sportsbook is offering a sign-up bonus of up to $1250. Few expect the shootout of sorts that transpired last year between the two teams. The 49ers and Bears combined for 55 points in a wild affair.

Justin Fields ran for over 100 yards against the 49ers last season.

Elijah Mitchell ran for well over 100 yards in that game against the Bears last season.

Now Trey Lance is starting for the 49ers.

Bears vs 49ers is going to be a fun game.

— Mitch Blatt NFL, IDP, and Travel (@MitchBlattNFL) September 9, 2022

A winning wager offers an implied probability of success of 75.31% but a profit of just $8.20 on a $25 bet.

49ers vs Bears Prediction

The road team has won five of the last six games in this series and against the spread. There are a few more sobering numbers for Chicago to consider as well. San Francisco allowed the third fewest yards on defense and was ninth in points yielded.

Again, the expectation is to figure a game that is a bit lower scoring than last year’s contest. The mobile quarterbacks (Trey Lance and Justin Fields) will make this interesting. Ball security will be an issue with windy and rainy conditions potentially in the forecast.

Justin Fields OVER 33.5 rushing yards -114: He's gonna be running for his life out there as he was when he faced the 49ers last season when he took off 10 times, running for 103 yards. He closed out last season topping 33.5 in 6 of his last 7 games.

— Joe Osborne (@JTFOz) September 9, 2022

The 49ers do like playing on grass and have won six of their previous seven games ATS. If the weather clears up a bit, consider the over. If not, ponder the under.

Pick: San Francisco 49ers, -7.0 (-110); risk 1 unit