Opening NFL Week 2 Odds – Point Spread, Moneyline & Total for All 16 Games

• Odds are starting to be released for NFL Week 2, which runs from Thursday, Sep. 12, to Monday, Sep. 16
• The Week 2 slate is highlights by the  Buffalo Bills vs Miami Dolphins on Thursday Night Football
• Below, see the opening NFL Week 2 odds for every game on the schedule

A handful of late-afternoon Week 1 games are still in progress, but oddsmakers have already turned their attention to Week 2 in the NFL, with the odds for more than half of the matchups already posted.

Week 2 starts with a heavyweight AFC East tilt between the Buffalo Bills and Miami Dolphins on Thursday Night Football on Sep. 12 and wraps up with the Atlanta Falcons vs Philadelphia Eagles on Monday, Sep. 16. The other 14 games are all on Sunday, Sep. 15.

The table below lists the opening moneyline, point spread, and game total for every Week 2 NFL game in chronological order. The table will be updated as more Week 2 NFL lines are posted.

NFL Week 2 Odds

The early Week 2 NFL odds list the Bills vs Dolphins matchup on TNF with the narrowest spread of the week with Miami opening as just 1.5-point home favorites.

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Odds as of Sep. 8 at FanDuel and DraftKings. Get the latest promo code for DraftKings to bet on NFL Week 2. 

Biggest NFL Week 2 Point Spread: Ravens -8.5 vs Raiders

Only one point spread on the board in the Week 2 NFL odds is more than a touchdown, and that comes in the Las Vegas vs Baltimore matchup where the 0-1 Ravens are 8.5-point home favorites over the 0-1 Raiders. Baltimore went toe-to-toe with defending-champion Kansas City on TNF in Week 1 (meaning they’ll have extra time to prepare), coming out on the wrong end of a 27-20 scoreline.

The Raiders, meanwhile, were outclassed 22-10 on the road by the Chargers. New QB Gardner Minshew wasn’t terrible, going 25/33 for 257 yards, one TD, and one interception, but a -3 turnover margin spelled doom for the Silver and Black.

Vikings Big Underdogs to 49ers Despite Impressive Season-Opening Win

If you want proof that oddsmakers are taking the Week 1 results with a grain of salt, look no further than the San Francisco vs Minnesota matchup in the Twin Cities. The Vikings are coming off a resounding 28-6 win on the road against the New York Giants, a game they controlled from start to finish. Yet Minnesota has opened as nearly a touchdown underdog at home to the reigning NFC-champion 49ers.

New starter Sam Darnold was on point, going 19/24 for 208 yards and two touchdowns while spreading the ball around to one of the NFL’s best receiving corps. The Minnesota defense, meanwhile, held the Giants to just 240 total yards of 68 plays (3.5 yards per play) while also generating two interceptions.

Absolutely inexcusable from Daniel Jones on his 2nd Interception today, behind the receiver into double coverage. pic.twitter.com/6EiCRnxZr0

— Joe Vostal (@jvostal42) September 8, 2024

San Francisco, which faces Aaron Rodgers and the New York Jets on Monday Night Football tomorrow, will be on a short week.

Harbaugh’s Chargers 4.5-Point Road Favorites at Abysmal Panthers

After a horrendous 2-15 campaign last year, the Carolina Panthers picked up where they left off in Week 1 of 2024, getting embarrassed 47-10 by division-rival New Orleans. Carolina was down 17-0 by the end of the first quarter and trailed 30-0 late in the first half before finally getting on the board.

Sophomore QB Bryce Young showed no growth from his disastrous rookie season, going just 13/30 for 161 yards and two interceptions.

The Chargers, meanwhile, took care of business as 3.5-point home favorites against the Raiders, overcoming an early 7-3 deficit en route to a decisive 22-10 victory in the first game of the Jim Harbaugh era. Former Raven JK Dobbins was absolutely electric spelling Gus Edwards, rushing for 135 yards and a touchdown on just 10 carries, including this 61-yard scamper.

jk dobbins the man that u are

📺 | @nfloncbs pic.twitter.com/YZGjq4cXYm

— Los Angeles Chargers (@chargers) September 8, 2024

Dobbins went nearly 100 yards over his rushing-yard total of 36.5 in the Week 1 NFL props.

Despite Carolina’s brutal Week 1 showing and LAC’s relatively strong start under Harbaugh, the Chargers have opened Week 2 as relatively slim 4.5-point road favorites against the worst team in the league at the moment.