NFL Week 7 Picks Straight Up – Predicted Upsets and Underdogs Showing Value

By Daniel Coyle in NFL Football
Published:

- Overachieving Jets and Seahawks lead the way on Week 7 upset picks
- 49ers’ home dominance and decades-long success against Chiefs lift their betting value
- Read on for this week’s bets bets to pull off upsets
Things didn’t go as planned with our picks last weekend, as the Chiefs, Jaguars, and Broncos fail to rise to the occasion. But opportunity knocks in Week 7, so read on to get the scoop on all our NFL Week 7 upset picks.
We’re backing a pair of overachieving squads heading into very winnable road games, as well as one NFC powerhouse listed as a home underdog despite their recent steady success on home turf.
NFL Week 7 Upset Picks
Matchup | Spread | Moneyline | Pick | Units |
---|---|---|---|---|
New York Jets vs Denver Broncos | DEN -1 | +100 | Jets | 1 |
Seattle Seahawks vs Los Angeles Chargers | LAC -5 | +192 | Seahawks | 1 |
Kansas City Chiefs vs San Francisco 49ers | KC -1 | +105 | 49ers | 1 |
Odds as of October 22nd at Caesars Sportsbook.
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NFL Week 7 upset picks: Jets Poised to Extend Win Streak
Victorious in just two games last season, the Jets have already doubled that win total during their current three-game win streak. However, that recent success has yet to have an impact on the sportsbooks, where New York lags as a 1-point underdog in the NFL Week 7 odds ahead of Sunday afternoon’s visit to Denver.
So some fun for #JetsTwitter:
The Jets have already matched their 2021 win total
The Jets are 4-1 since the “Receipts” started being kept
The Jets have outscored their opp 91-47 in their 1st 3 game winning streak since 2019#TakeFlight
— Stephen Zantz (@szantz) October 16, 2022
The Jets’ current surge coincides with the return of starting quarterback Zach Wilson from an injury. But it is tough to overlook the performance of the New York defense, which has limited opponents to just 15.7 points per game and just one total scoring pass over that stretch.
Russell Wilson (hamstring) is listed as questionable and will be a game-time decision against the Jets pic.twitter.com/PyTLGSKz81
— B/R Gridiron (@brgridiron) October 21, 2022
Currently, the lowest-scoring team in the NFL, the Broncos’ attack misfired again in last week’s loss to Los Angeles and has now failed to score a TD in two straight contests. With Denver also struggling with a rash of injuries – including a hamstring injury that limited quarterback Russell Wilson in practice all week and left his status as questionable for Sunday – look for their woes to continue.
Injuries a Factor as Seahawks Visit Chargers
The Seattle Seahawks extended their steady start last weekend with their third outright victory as betting underdogs, knocking off the visiting Arizona Cardinals 19-9. After opening their campaign amid tempered expectations in the wake of Russell Wilson’s offseason departure, this team has found ways to exploit the weaknesses and mistakes of struggling opponents in each of their three wins.
The Seahawks WIN!
19-9 over Arizona and they end the Cardinals' 10-game regular season road win streak.
— Field Gulls (@FieldGulls) October 16, 2022
Now it’s the Los Angeles Chargers’ turn to face the Seahawks, perched as 5-point home favorites in the Week 7 NFL odds. The Chargers return to action on limited rest after extending their current SU win streak to three games with a 19-16 win over Denver on Monday Night Football. But after seeing his run of 27 straight games with a scoring pass end in last week’s win, questions linger about the health of quarterback Justin Herbert, who was limited by a rib injury earlier in the season.
The Chargers overcame so many injuries to win that game. Because of that they’re still alive in the AFC West. pic.twitter.com/WepyToIlqy
— Endzoneblog Ad Network (@EndzoneblogAds_) October 18, 2022
Joining Herbert in the Chargers clinic are receivers Keenan Allen and Josh Palmer, as well as kicker Dustin Hopkins, whose four field goals were the difference in last week’s win. Los Angeles has also struggled to shut down opposing rushers and will have its hands full containing Seahawks rookie Kenneth Walker III, who has compiled 185 rushing yards and two scores over the past two weeks.
Can 49ers Extend Home Win Streak?
It has been a tale of two teams in San Francisco, where the 49ers have lost four of five on the road, but enter Sunday’s home date with the Kansas City Chiefs riding a six-game home win streak.
Reeling from last weekend’s stunning 28-14 loss in Atlanta, the 49ers softened the blow by pulling the trigger on a deal with Carolina to acquire rusher Christian McCaffrey. He is expected to be in the lineup when they hit the gridiron at Levi’s Stadium on Sunday as 1-point underdogs. The addition of McCaffrey bolsters a backfield that struggled to produce against the Falcons. It could however cause huge headaches for a Chiefs defense that has been exploited by big rushing performances in each of the past two weeks.
#49ers Super Bowl odds shorten significantly following trade with #Panthers for McCaffrey: https://t.co/6QPdecdZW8 #gamblingtwitter @SBD
— Bob Duff (@asktheduffer) October 22, 2022
Niners quarterback Jimmy Garoppolo should also enjoy a little more breathing run after tossing two picks last week, thanks to injuries among the Chiefs’ defense. Most notable among those is cornerback Rashad Fenton, who has been ruled out of Sunday’s game with a hamstring injury.
Mike Danna and Joe Thuney are questionable for Sunday's game. Rashad Fenton is out.
— Kansas City Chiefs (@Chiefs) October 21, 2022
Adding to the appeal of the Niners as an upset pick is their current six-game home win streak versus the Chiefs that dates back to 1971, during which Kansas City has scored an average of just nine points per game.

Sports Writer
Daniel has been writing about sports and sports betting for over 23 years. The seasoned pro has contributed to the likes of Sports Illustrated, Sportsnet, NESN, Bleacher Report, OddsShark, the Globe and Mail, and The Nation magazine.