New York Giants vs Buffalo Bills Same-Game Parlay Picks for Sunday Night Football

• The struggling and injury-riddled New York Giants visit the Buffalo Bills on Sunday Night Football in Week 6
• The Giants will be without starting QB Daniel Jones, meaning former Bills pivot Tyrod Taylor will start under center
• See the best Giants vs Bills same-game parlay picks, below

The New York Giants (1-4, 1-2 away, 0-5 ATS) have a mountain to climb on Sunday Night Football this evening, travelling to Buffalo to face the Bills (3-2, 2-1 home, 3-2 ATS) while suffering from significant injuries on the offensive side of the ball.

With starting QB Daniel Jones out with a neck injury, the Giants are forced to turn to former Buffalo starter Tyrod Taylor.

Giants vs Bills Same-Game Parlay Picks

Today’s NYG/BUF same-game parlay starts with James Cook to score at least one touchdown, while also banking on the Bills winning the first half and the game, plus the game total going over 41.5. Kickoff at Orchard Park is scheduled for 8:20 pm ET.

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NYG vs BUF same-game parlay odds from FanDuel. Get a FanDuel Sportsbook deposit bonus to wager on Week 6 Sunday Night Football. 

NYG vs BUF Same-Game Parlay Pick #1: James Cook Anytime TD Scorer

Coming into this game, the Giants ranked third-last in the NFL at stopping the run. With the Giants vs Bills injury reports showing New York decimated at linebacker, their play in that department isn’t likely to get better, and the Bills should have a lot of success on the ground.

Cook only has one touchdown on the season, but that shouldn’t be a huge cause for concern. He’s definitively taken over as the Bills lead back and, in a game that’s likely to get out of hand on the scoreboard, offensive coordinator Ken Dorsey will be eager to reward Cook’s efforts with red zone carries against a bad run defense.

James Cook is averaging the fourth most yards per reception (9.1) while the Giants allowed 8.1 yards per reception to RBs since 2022 —the worst in the league. pic.twitter.com/k9oVH8LDiT

— Jeremy (@PopesFFH) October 13, 2023

My colleague outlined in the Giants vs Bills player props why Cook is a good bet to go over his rushing-yard total, and even if Cook doesn’t get in on the ground, he’s a more-than-capable receiver who will eventually find the end zone through the air in his promising career.

Giants vs Bills SGP Pick #2: Bills Win 1H and Full Game

As outlined in the Giants vs Bills predictions, Buffalo has had a knack for blowing out bad teams in the Josh Allen era. They tend to start fast and don’t take their foot off the gas. They’ve continued that trend this season with massive wins over Las Vegas (38-10), Washington (37-3), and Miami (48-20).

They led those games at halftime by 11, 16, and 17 points, respectively. That’s why, despite only going 3-2 overall, they still have an AFC-best +79 point differential.

I love the Bills’ first-half ATS (-8.5) and will be absolutely stunned if this game ever feels competitive.

NYG vs BUF SGP Pick #3: Total Points Over 41.5

The last leg of this Giants vs Bills same-game parlay is over the alternate total of 41.5.

With New York’s defense already underperforming and then losing more pieces after Week 5, the Bills have a realistic chance of going over this alt total themselves. Buffalo is averaging 31.8 points per game even with two ugly offensive performances on their resume (16 points vs Jets in Week 1 and 20 points vs Jaguars in London in Week 5).

Even if the Bills only reach their season average of 31, the G-Men would need just 11 points for the total to reach 42, which is not a big ask. That’s especially true in a game that the Bills are likely to fully control; defensive intensity often lags when your team has a two or three-touchdown lead. Tyrod Taylor has been with the Giants for over two years and will be plenty familiar with the offensive scheme. If/when the Bills corners are sagging off in garbage time, expect the former Bill to put up at least a handful of points against his former team.