New York Giants vs Minnesota Vikings Odds, Lines, Spread, and Picks NFL Week 16

By John Perrotto in NFL Football
Published:

- The Vikings are four-point home favorites over the Giants on Saturday
- Minnesota has clinched the NFC North title
- A look at the Giants vs Vikings odds and matchup can be found below with a prediction
Two rookie coaches having fine debut seasons square off when Brian Daboll’s New York Giants visits Kevin O’Connell’s Minnesota Vikings at 1 p.m. ET Saturday at U.S. Bank Stadium in Minneapolis. Read on for an analysis of the New York Giants vs Minnesota Vikings
The Giants (8-5-1, 4-2 road) ended a 0-3-1 stretch by beating the Commanders 20-12 in Washington last week. New York currently holds the sixth playoff spot in the NFC and can clinch a postseason berth with a win Saturday and some help from other teams.
The Vikings (11-3, 7-1 home) secured their first NFC North title since 2017 last week when they rallied from a 33-0 deficit last week to beat the visiting Indianapolis Colts 39-36 for the biggest comeback in NFL history. It was the Vikings’ third win in their last four games.
Fox will televise the game.
Giants vs Vikings Odds
Team | Moneyline | Spread | Total |
---|---|---|---|
New York Giants | +175 | +4 (-110) | Over 48 (-110) |
Minnesota Vikings | -210 | -4 (-110) | Under 48 (-110) |
Odds as of December 23rd at Caesars Sportsbook.
The Vikings are favored by four points and are -210 picks on the moneyline in the NFL odds, giving them an implied win probability of 67.74%. Minnesota has +2500 Super Bowl championship odds and the Giants are listed at +10000.

Recent History
The teams last played in 2019 with the Vikings winning 28-10 on the road. Kirk Cousins passed for 306 yards and two touchdowns and Dalvin Cook had 218 scrimmage yards – 132 rushing and 86 receiving.
The Vikings have won the last four meetings in Minnesota. That includes a 24-10 victory in 2016, the only time the teams have faced each other at U.S. Bank Stadium.
Giants Offense vs Vikings Defense
The Giants would love to get running back Saquon Barkley untracked.
Barkley is fourth in the NFL with 1,170 rushing yards. However, he has been held to 239 yards on 71 carries in the last five games while catching 18 passes for just 97 yards.
Daniel Jones’ 583 rushing yards is a Giants single-season record for a quarterback. He is fifth among NFL QBs in rushing.
This epic Daniel Jones run didn't count…
(via @NFL)pic.twitter.com/0n5r7lkBPj
— Bleacher Report (@BleacherReport) September 17, 2021
Kicker Graham Gano has made 15 of 16 field goal attempts over the last 10 games. His three games of multiple 50-plus-yard field goals are the most in the league.
Vikings Offense vs Giants Defense
The Giants are 26th in total defense and 16th in pass defense. They face a tough matchup against Vikings wide receiver Justin Jefferson.
Jefferson’s 111 receptions and 1,623 receiving yards lead the NFL. He is just the third player in league history with three consecutive 1,600-yard seasons and has done so in his first three years.
Jefferson’s NFL MVP odds are +15000. Hopefully, he doesn’t really get hurt doing the Griddy.
Justin Jefferson hit the fake injury griddy again https://t.co/P37p4DUIX0
— alex (@highlightheaven) December 17, 2022
The Vikings’ best hope of stopping the passing game might be by putting pressure on Cousins. Rookie outstanding linebacker Kayvon Thibodeaux is coming off a game in which he had a season-high 12 tackles, forced a fumble that he recovered for a touchdown, and had three tackles for loss in the first quarter.
Cousins leads NFL quarterbacks with seven game-winning drives in 2022. He has had two of his five 400-yard games in five seasons with the Vikings in the past two weeks.
Injury Report
The Giants will be without cornerback Adoree Jackson (knee), who will miss his fifth straight game, and offensive line Shane Lemieux (toe).
Sitting out his third game in a row for the Vikings will be center Garrett Bradbury (back). Linebacker Eric Kendricks (hip) and cornerback Cam Dantzler (ankle) are listed as questionable.
 New York Giants vs Minnesota Vikings Prediction
It will be interesting to see what the Vikings’ mental state is coming off such an emotional victory. The Giants have been tough on the road this season and have what it takes to at least keep the game close.
Pick: Giants +4 (-110)
Season Record: 4-5 (-1.5 units) ATS

Sports Writer
John Perrotto has been covering and writing about sports for various outlets for over 40 years. His work has appeared in the likes of USA TODAY, ESPN.com, SI.com, Forbes.com, The Associated Press, Baseball Digest, and more. John is based out of Beaver Falls, PA.