Jacksonville Jaguars vs Indianapolis Colts – Odds, Lines, Spread, and Picks NFL Week 6

• The Indianapolis Colts are -2 favorites over the Jacksonville Jaguars on Sunday
• The Colts squeaked past the Broncos last week, while the Jaguars lost to the Texans.
• See the Jaguars vs Colts picks and odds ahead of their Week 6 clash, and our pick below

So, the Jacksonville Jaguars vs Indianapolis Colts matchup on Sunday will not be wet. Thankfully, Indianapolis plays in a dome.

Now, even with the struggles of the Jaguars, they are only 2-point road underdogs vs the Colts.

Granted, the Jaguars were a feel-good story for a cup of coffee. They are 2-3 now after two one-score losses. However, Indianapolis seems to have some considerable issues themselves.

Both teams have some minor issues but Jonathan Taylor is questionable for the Colts after missing the Broncos game last week (ankle).

It all gets started Sunday from Lucas Oil Stadium at 1pm ET, in a game that can be seen live on CBS.

Jaguars vs Colts Odds

Odds as of October 14th from Barstool Sportsbook. 

Indianapolis’ odds have moved around from 1 to 2 points. The over has wobbled back to 42 from 43 earlier in the week.

Now, the NFL Betting Trends curve a bit toward the road team. A whopping 83% of the bets placed are for the Jaguars to cover the spread but the money is almost a 50-50 split.

That movement with the total has not had that much impact. The over is only being bet 58% of the time.

Jaguars Betting Outlook

This game has now become very important for the Jaguars and Doug Pederson. He probably did not expect Jacksonville to lose consecutive games by one score. The Houston loss was sloppy even despite a solid performance from the defense.

Jacksonville stumbled after the four-turnover game from Trevor Lawrence in Philadelphia. Lawrence tossed two more interceptions in the home loss to Tennessee, which dropped the Jaguars to 2-3.

FAN FRIDAY | What's up with Trevor Lawrence? Should Doug Pederson stop calling plays? What about the left guard position? Seriously, what's up with Trevor? We open the mailbag and answer your questions. https://t.co/guIg5sr1DD

— Florida Times-Union (@jaxdotcom) October 14, 2022

The Jaguars’ rush defense struggled against the Eagles and was gouged for 210 yards. However, it did look better versus Houston last week allowing 116 yards. Overall they still rank sixth in yardage allowed and fifth in yards per carry. They yielded a mere 54 yards to Indianapolis in their Week 2 clash.

What could help Jacksonville is if Jonathan Taylor does not play. Some would argue that makes little difference considering the Jaguars have beat Indianapolis in four of the last six meetings. All of those wins were at home, however.

The Colts’ defense is quite proficient against the run. Indianapolis allows the fourth least amount of yards in the NFL and is second in yards per carry yielded. Jacksonville must attack through the air with Trevor Lawrence.

Jaguars quarterback Trevor Lawrence said he needs to learn the art of minimizing bad plays #JacksonvilleJaguars #Jaguars #Jags #GoJags #JagsFans https://t.co/SNbBz6VtqI

— Jaguars Fans (@JaguarsViews) October 13, 2022

Again, one of the good things for Jacksonville is that Indianapolis is limited with offensive potential. Jacksonville is fourth in the league in points allowed (80). DC Mike Caldwell has this team playing well on the defensive side of the ball.

Jacksonville just needs Lawrence to get out of his own way. It’s that simple.

Colts Betting Outlook

At home, the Colts have a chance to get over .500 and try to get closer to the top of the AFC South.

Frank Reich is on the hot seat as the Colts’ offense ranks dead last in terms of points scored (69). They have averaged 13.8 points per game and have not scored more than 20 points in any game.

The Colts’ offense has just one rushing touchdown and averages a mere 3.6 yards per carry (29th in the NFL). Their offensive line has not created holes and the rotating running back issues do not help.

Jonathan Taylor was back at practice today, a good sign for Sunday and a testament to the year-round scientific approach the Colts take with running backs.

Good insight from Scottie Montgomery. Good read from @THEAkeemGlaspie: https://t.co/PwPfuWAXrk

— Nate Atkins (@NateAtkins_) October 13, 2022

Again, this week could be rough even if Taylor returns as Jacksonville takes pleasure in stuffing the run. The problem is no one is scared of the Colts’ passing game.

This is because Matt Ryan has tossed seven interceptions on the season. Even last week, the Colts managed four field goals mainly because Ryan just could not complete passes in the red zone. It has been a recurring pattern all season.

The Colts are one of the worst teams at gaining yards and causing turnovers. Their possession time ranks near the middle-of-the-pack but 25th in yardage gained. The percentage of offensive drives ending in a score is less than 20 which is now 31st in the league.

The worst news is that 38-year-old Matt Ryan has been sacked a ton and teams simply do not feat his arm.

Carson Wentz, Matt Ryan, and Russell Wilson are really competing for worst quarterback in the league with no one really even close despite the fact that fact that two third stringers are starting in the AFC East and Cooper Rush has started 4 games #Commanders

— Quintonio Brown (@QuintonioBrown) October 14, 2022

If any team can play ugly games, it is the Colts. If Jacksonville gets drawn in, this could be a long, long afternoon.

Jaguars vs Colts Pick

The dilemma with this AFC South battle is it could be an exercise in futility. Can either of these teams score more than 24 points against each other? The Jaguars need to minimize mistakes against a Colts team that has a hard time creating them.

That @Colts win likely saved Frank Reich’s job. Bad QB play, injured RB, endless TO’s and were headed to 1-3-1 until Wilson had back to back drives die in the endzone.

And now, a win at home next week vs the @Jaguars would put this Colts team at 3-2-1, and in first place! 🤯 pic.twitter.com/017slV2vfm

— Mike Lawrence (@AwesemYo) October 7, 2022

The concern for Jacksonville is that some believe Matt Ryan is getting healthy. Maybe.

The worry for Jacksonville is can Trevor Lawrence take what is given to him (underneath routes).

This game feels like another low-scoring AFC South struggle. Points will be at a premium.

The Pick: Under 42.0 (-110) 1 unit

2022 Record: 4-1; Overall: 4-1, +2.4 units