Broncos vs Seahawks Odds, Lines, Picks, and Predictions for Week 1 Monday Night Football

By Bryan Thiel in NFL Football
Published:

- The Denver Broncos and the Seattle Seahawks cap off Week 1 with the first Monday Night Football game of 2022
- Russell Wilson’s Broncos debut comes against the team that traded him in the offseason
- See the Broncos vs Seahawks odds ahead of Monday Night Football
After a messy divorce that was a long time coming, Russell Wilson won’t have to wait long to get his revenge. Wilson’s Broncos visit the Seahawks in Seattle for the first installment of Monday Night Football at 8:15 pm ET on ESPN for the 2022 season.
In fact, Monday night marks the first time since 2011 that a QB not named Wilson has started Week 1 for Seattle. That year it was Tarvaris Jackson who got the start.
This year it’ll be Wilson against Geno Smith.
Broncos vs Seahawks Odds
Team | Moneyline | Spread | Total |
---|---|---|---|
Denver Broncos | -315 | -6.5 (-110) | Ov 44 (-112) |
Seattle Seahawks | +245 | +6.5 (-110) | Un 44 (-109) |
Odds as of September 11th from Barstool Sporstbook
Russell Wilson is no stranger to being favored at Lumen Field, all it means in 2022 though is that the Broncos are road favorites. They were also favored by one of the bigger spreads in the Week 1 NFL odds.
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Not surprisingly, public betting trends are significantly fading the Seahawks. An interesting side note however, is the fact both the money and the amount of bets are siding with the over.
The public is eyeing a blowout.
Broncos vs Seahawks Injury Report
While Wilson’s offense will be at full strength in his return to Seattle, there is a key injury for the Broncos on the defensive side of the ball.
Broncos OL vs. Seahawks defensive front is a matchup that isn't getting enough attention
— Joe Rowles (@JoRo_NFL) September 9, 2022
Linebacker Josey Jewell was downgraded to out on Sunday’s injury report. Jewell is Denver’s leader on defense, pairing in the middle with Jonas Griffith.
Week 1 Injury Report
Broncos | Injury, Status | Seahawks | Injury, Status |
---|---|---|---|
Josey Jewell, LB | Calf, Out | Tyler Ott, LS | Shoulder, OUT |
Randy Gregory, OLB | Shoulder/Knee, Questionable | Alton Robinson, LB | Knee, OUT |
KJ Hamler, WR | Knee/Hip, Questionable | Artie Burns, CB | Groin, Doubtful |
Billy Turner, OL | Knee, Questionable | Kenneth Walker III, RB | Abdomen, Questionable |
N/A | N/A | Damien Lewis, G | Knee/Ankle, Questionable |
Despite being listed as questionable, it wouldn’t be surprising to see rookie running back Kenneth Walker inactive. He was a DNP all week as he recovers from hernia surgery.
Offseason signing Artie Burns may be waiting to make his Seattle debut too. He’s been battling a groin injury on and off since training camp.

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Russell Wilson on Monday Night Football
If there’s one thing football fans know about Russell Wilson, it’s that he lives for the big moment.
And during the regular season there are no bigger moments than Monday night. And throughout his career, Wilson has thrived under the ESPN spotlight.
Russell Wilson Career Stats: Sunday vs Monday
85-46-1 | Record | 10-3 |
64.8% | Completion Percentage | 66.2% |
237.7 | Yards per Game | 219.5 |
1.86 | TD per Game | 1.7 |
.58 | INT per Game | 0.38 |
101.2 | Rating | 103.6 |
There isn’t even a homefield advantage here for the Seahawks. Sure emotions will be running high for Wilson, and after the inevitable tribute the cheers will ultimately turn to boos, but he’s heard it all before from the other side.
New Seahawks captain Tyler Lockett on good friend Russell Wilson’s return Monday night with the Broncos: “I get it…but I think Seattle should cheer him on for everything that he’s done. He’s an amazing guy.” @thenewstribune pic.twitter.com/xXuDJyMrAd
— Gregg Bell (@gbellseattle) September 6, 2022
This is a guy that’s used the 12th Man to his advantage for years. He’s seen Aaron Rodgers and Tom Brady get hit with the best Seattle can throw at them. If anyone knows what he’s in for, it’s Wilson.
Can Geno Smith Keep Pace with Wilson?
While Drew Lock was one of the pieces heading back to Seattle in the trade, it was Geno Smith who won the starter’s job in camp. And it was Smith who filled in for Wilson last year when he injured his finger.
Although Smith’s numbers weren’t bad, his record was. Smith threw five touchdowns to just one interception, with a 68.2% completion percentage. He only averaged 175.5 yards-per-game though, and the only win he was able to get Seattle was against the Jacksonville Jaguars.
DK Metcalf's stats with Geno Smith at QB last season (Weeks 5-8):
🟢 86.2 receiving grade
🟢 295 yds
🟢 5 tdsIs a Geno Smith X DK Metcalf connection in the making 👀? pic.twitter.com/n55AUoQrFB
— PFF SEA Seahawks (@PFF_Seahawks) September 6, 2022
Yes Seattle has weapons like DK Metcalf and Tyler Lockett, but it’s tough to see Smith stressing the Broncos’ defense too much.
Broncos vs Seahawks Pick
Wilson will come in fired up, and the Broncos will likely be pretty motivated to win it for him. And asking the Seahawks to keep pace without a comparable talent under center on the other side? It’s a tall task.
Seahawks fans have begged for years to let Russ cook. Now they’ll finally see it, it’ll just be in the wrong colors.
The Pick: Denver Broncos -6.5 (-110); 1 unit

Sports Writer
Bryan has spent the last decade working in the sports industry. From the sidelines in the OHL and Rugby League to behind the scenes at TSN, Bryan has a wealth of experience with a soft spot for props and parlays.