49ers vs Packers Odds, Picks & Predictions (Week 12)

• The Green Bay Packers are 5.5-point favorites over the San Francisco 49ers for their Week 12 matchup
•  49ers’ QB Brock Purdy is out with a shoulder injury
• Check out the 49ers vs Packers odds, picks and prediction below

Two teams in the thick of the NFC Playoff chase collide in Week 12 when the San Francisco 49ers (5-5) visit the Green Bay Packers (7-3). The football betting lines shifted dramatically Friday when it was announced 49ers’ pivot Brock Purdy (shoulder) would be sidelined, as well as EDGE Nick Bosa (hip/oblique).

49ers vs Packers Odds

San Francisco originally opened as a 2.5-point road favorite, but it’s flipped completely with their injury woes, with Green Bay now sitting at -5.5 on the spread. Still, a whopping 70% of the tickets and 57% of the handle is on ‘Frisco.

Odds as of Nov 23 at Caesars Sportsbook. Be sure to check out the best Caesars Sportsbook promos before placing a bet on any Week 12 NFL matchup.

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At one point, the total was at 48.5, but that’s now down to 44.5. The NFL public betting percentages are banging the Under, taking 74% of the bet and 67% of the money.

Kickoff goes at 4:25 pm ET from Lambeau Field in Green Bay, WI. FOX is carrying the broadcast.

Niners Turn to Brandon Allen in Critical Game

After blowing a fourth-quarter lead in a crushing 20-17 loss to the Seattle Seahawks last week, the 49ers have dropped all the way to last in the NFC West.

The good news, though, is that at 5-5, they are still just one game out of first place in that logjam of a division.

With the injury to Purdy, however, the Niners will turn to journeyman Brandon Allen at pivot, making just his 10th career start since entering the league as a sixth-round pick in 2016. Josh Dobbs is listed as his backup.

This is probably Brandon Allen's most notable preseason play. pic.twitter.com/MIJ34y2TBR

— Wendell Ferreira (@wendellfp) November 23, 2024

Allen hasn’t started a game since the Cincinnati Bengals’ 2021 regular-season finale. He’s 2-7 as a career starter, and he’ll need to shake off some rust: Allen has thrown three passes in the last three seasons.

Fortunately, Christian McCaffrey now has two games under his belt after returning from injury, and Allen will lean on the league’s 8th-ranked rush attack. Last time CMC saw the Pack was in the NFC Divisional playoff, and he ran for 98 yards and a pair of TD’s.

A big help would be if hulking left tackle Trent Williams (ankle) will be able to go, currently listed as questionable.

Defensively, Bosa’s ability to pressure the QB will be lacking, but there’s still plenty of talent to work with on that side of the ball, as the 49ers are Top 10 in both rush and pass yards allowed.

Packers Try to Find Consistency

Green Bay will try to take advantage of this opportunity, and they can definitely use it.

Coming out of their bye week, they looked out of sorts against the Bears, needing a blocked field goal as time expired to escape with a 20-19 win.

PACKERS BLOCK THE FIELD GOAL FOR THE WIN.#GBvsCHI pic.twitter.com/gq8zbz965C

— NFL (@NFL) November 17, 2024

Quarterback Jordan Love has been Jekyll and Hyde all season, and Week 11 was no different, showing flashes of a guy on the board for NFL MVP odds, including running for the winning score late against the Bears.

However, he also threw his league-leading 11th interception of the season, and has been picked off at least once in each of his eight starts.

Green Bay does have the league’s fourth-best rushing attack, so balancing Josh Jacobs touches with Love in the passing game should be their formula Sunday.

49ers vs Packers Prediction

At 7-3 and with a game against Detroit in two weeks, Green Bay could still challenge for the NFC North title, but this game with San Francisco is a virtual must-win for that to happen.

Losing Purdy is a big blow for the Niners, but this is a chance for Kyle Shanahan to showcase his offensive chops, and draw up a game plan that can put up enough points to compete.

GENO!!!! TD @SEAHAWKS!!

📺: #SEAvsSF on FOX
📱: https://t.co/waVpO8ZBqG pic.twitter.com/ATSZeKJaOe

— NFL (@NFL) November 18, 2024

The Packers’ run defense is in the middle of the pack, and there will be chances for McCaffrey to put his imprint on this one.

The Niners’ biggest flaw is the inability to close out contests, allowing the second-most points in the final two minutes of regulation, and losing a league-high three games when holding a lead in the final 120 seconds.

Each of the last three games between these teams has been by three points, and I think it’s close again.

• Pick: 49ers +5.5  (-110)