Oregon vs Michigan State Pick, Prediction & Betting Line

• No.6 Oregon hosts Michigan State in Week 6 CFB action
• The Ducks are 23.5-point favorites heading into Friday’s clash
• Check out all our Oregon vs Michigan State picks & predictions

Oregon takes on Michigan State in a newfound Big 10 rivalry on Friday, October 4. The sixth-ranked Ducks are a perfect 4-0 after knocking off UCLA last week, while the 3-2 Spartans are coming off of a 38-7 drubbing at the hands of the Ohio State Buckeyes.

Dive into the Oregon vs Michigan State odds and our best wagers, below.

Oregon vs Michigan State Odds

Oregon heads in Friday night’s Big 10 showdown as massive 23.5-point favorites in the latest college football odds. The Michigan State vs Oregon total is currently set at 52 points.

Odds as of October 2 at DraftKings Sportsbook. Browse the best College Football Betting Apps for Michigan State vs Oregon.

Ducks Look Like CFP Contenders

Oregon’s super powered offense has scored 40 points per game, and rank tenth in points per play this season.

Dillon Gabriel has been spectacular under center, and has looked at home as a Duck. He’s tossed for 1,192 passing yards and nine touchdowns with just one interception while guiding the undefeated Oregon offense. The Oklahoma transfer has averaged 8.8 yards per attempt while completing 81.5 percent of his passes. He’ll be out to show he belongs in the conversation with the biggest names in college football with a statement win against a staple Big 10 program on Friday night.

Autzen AWAKENS 🏟️

Dillon Gabriel keeps it and @oregonfootball takes the lead 👏#B1GFootball on Peacock 💻 pic.twitter.com/ZfY2th0gQ3

— Big Ten Football (@B1Gfootball) September 8, 2024

On the other side of the ball, the Ducks defense have allowed just 4.6 yards per pass, good for fourth in the nation. Oregon has surrendered just 20 points per game, and only 150 passing yards per game so far.

Be aware, Oregon have won 10 straight games in at home in Eugene, but are just 2-5 ATS in their last seven games on Friday’s when playing at home.

Michigan State’s Lousy Offense Holding Team Back

Michigan State’s offense sits just 86th in total yards and 104 in points per game thus far. The Spartans inconsistent ground has put up 132.4 yards per contest.

Most concerningly, Michigan State’s offensive line has struggled in 2024.  They’ve allowed 10 sacks already and 31 tackles for loss. The Spartans sport an awful 45 PFF pass-blocking grade. On top of that, they’ve surrendered 46 pressures leaving quarterback Aidan Chiles out to dry. Chiles has been pressured on 46 drop backs in just five contests.

heading out west pic.twitter.com/U2MclSYBLD

— Michigan State Football (@MSU_Football) September 30, 2024

Defensive coordinator Joe Rossi’s unit has been slightly better than the offense allowing 23.8 points per game (56th), and 4.8 yards per play (34th). Plus, they’ve racked up 35 tackles for loss, 15 sacks (12th in the country) and five interceptions. Despite their opponents otherworldly offense, this Michigan State defense will be ready to play on Friday night. The college football betting trends show that only six percent of the action is on the Spartans.

It’s important to note, Michigan State are 4-2 against the spread in their last six road games. Although, they are an awful 3-9 straight up in their last 12 games as underdogs.

Oregon vs Michigan State Prediction

Michigan State has played half-decent football this season. However, they’ve yet to play an offense of the caliber of Oregon’s. The Ducks are a College Football Playoff contender and will put up plenty of points in this one.

On the other side, the Spartans putrid offense will give bettors pause. Having said that, they’ve scored over 17 points per game, and a few garbage time touchdowns can help get us to the over.

• Oregon vs Michigan State Pick: Over 52 (-112)

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