Opening Week 5 College Football Odds, Spreads & Lines: Ohio State, Miami Big Road Favorites
By Brady Trettenero in College Football
Published:
- Ohio State and Miami face road tests with big spreads in the opening Week 5 college football odds
- Alabama faces a much tighter SEC line as Mississippi State looks to follow up its win over Missouri
- See the early Week 5 spreads, totals and moneylines, plus the matchups worth a closer look
Ohio State at Iowa and Miami at Clemson lead the opening Week 5 college football odds. The Buckeyes are laying two touchdowns at Kinnick Stadium, while the Hurricanes are 18.5-point road favorites in Death Valley.
There is a full SEC undercard behind them. Alabama visits Mississippi State, Florida heads to Missouri after scoring 52 points against Ole Miss, and Auburn travels to Tennessee.
The table below brings together the early Week 5 spreads, totals and moneylines. Compare these early prices with live college football odds as the rest of the slate gets priced this week.
Week 5 College Football Odds
Here is the full table incorporating the complete slate of Week 5 NCAAF odds provided in your prompt, structured with the Away Team listed first for each matchup:
Early Week 5 odds from DraftKings as of Sept. 27; away team listed first. Compare prices across College football betting apps before taking a side.
These are current early quotes, not historical openers, and more games should fill in over the next few hours. Vanderbilt at Georgia carries the biggest number on the board at 24.5, with Notre Dame laying 21.5 at North Carolina right behind it.
The totals split the board neatly. Ohio State at Iowa and Michigan State at Wisconsin share the lowest total at 44.5, while Alabama at Mississippi State and Louisville at NC State share the top mark at 59.5.
For the tighter games, it is worth running a price comparison on prediction market apps. Check the contracts at Kalshi and Polymarket before deciding where to take a side, matching the same outcome and accounting for fees.
Ohio State vs Iowa Odds
- Spread: Ohio State -14 (-110) / Iowa +14 (-110)
- Total: 44.5 (Over -110 / Under -110)
- Moneyline: Ohio State -650 / Iowa +470
The Ohio State vs Iowa odds have the Buckeyes laying two touchdowns. A 14-point win would be a push, while the 44.5 total shares the lowest mark on the board.
The Buckeyes got here by handling Illinois 42-19. Julian Sayin went 27 of 36 for 367 yards and accounted for five total touchdowns, and Jeremiah Smith caught 12 balls for 217 yards and four scores.
Iowa is coming off a 20-19 win at Michigan. The Hawkeyes now return home to face an Ohio State offense that just put up 42 points, making this one of the week’s most interesting matchups.
Miami vs Clemson Odds
- Spread: Miami -18.5 (-110) / Clemson +18.5 (-110)
- Total: 51.5 (Over -110 / Under -110)
- Moneyline: Miami -1350 / Clemson +800
The Miami vs Clemson odds require a 19-point Hurricanes win to cover. The Hurricanes are also -1350 on the moneyline, meaning a $135 wager would profit $10 if they win outright. Clemson’s +800 price would return $800 profit on a $100 upset bet.
Miami buried Central Michigan 52-3 in Week 4. Clemson took care of California 24-10 on Friday night, but the Tigers now face a much bigger test against the Hurricanes.
Alabama vs Mississippi State Odds
The Alabama vs Mississippi State odds have the Tide laying just 4.5 in Starkville, with a 59.5 total that ties for the highest on the board. The Tide side costs -105 while Mississippi State with the points is -115, making Alabama the cheaper side at the same 4.5-point spread.
Alabama ran away from South Carolina 49-18. Mississippi State beat Missouri 31-24, and a field-goal loss at home would still cash for the Bulldogs.
Florida vs Missouri Odds
The Florida vs Missouri odds put the Gators at -5.5 with a 56.5 total and a -218 moneyline. Missouri comes back at +180 on the moneyline. The Tigers cover +5.5 with an outright win or a loss by five points or fewer.
The Gators arrive off a 52-28 win over Ole Miss, while Missouri lost 31-24 at Mississippi State. Florida’s offense is the story to watch as it tries to carry that scoring surge onto the road.
Other Notable Week 5 Lines
Penn State is a 4.5-point favorite at Northwestern after losing 24-20 to Wisconsin, and Louisville is laying 6.5 at NC State following a 30-27 loss to Wake Forest. Both are road chalk coming off defeats.
The Auburn vs Tennessee odds have the Volunteers favored by 7.5 at home after falling 20-17 to Texas. BYU is giving 6.5 at TCU, and Pittsburgh gets six points at Virginia Tech in the earliest game currently posted.
Lead NHL & NCAAF Editor
Brady is the lead NHL and College Football editor at Sports Betting Dime, where he specializes in betting odds and data-driven analysis. Brady has over 10 years experience working in sports media, with work published by outlets such as ESPN, CBS Sports, Yahoo! Sports and Fox Sports.
