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Opening College Football Week 10 Odds, Spreads & Early Predictions
By Sascha Paruk in College Football
Published:
- The Week 10 NCAAF slate features a huge matchup between #4 Ohio State and undefeated #3 Penn State
- Current #1 Oregon travels to Ann Arbor to face 5-3 Michigan
- Below, see the opening Week 10 college football odds plus early picks and lines to target
The Week 9 slate is in the books and the Week 10 NCAAF odds have already been released. Week 10 includes a massive top-five clash between the #4 Ohio State Buckeyes and #3 Penn State Nittany Lions at Beaver Stadium in noon ET. Later in the day, the “World’s Largest Outdoor Cocktail Party” will take place at EverBank Stadium Jacksonville as Florida and #2 Georgia renew hostilities. The table below lists the opening Week 10 college football odds for all games on the board. More will be added as odds are released.
Week 10 College Football Odds
| Team | Spread | Moneyline | Total | Date/Time |
|---|---|---|---|---|
| New Mexico State | +9.5 (-110) | +255 | O 47.5 (-110) | Tuesday, Oct. 29 |
| FIU | -9.5 (-110) | -320 | U 47.5 (-110) | 7 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Louisiana | +3.5 (-110) | +138 | O 61.5 (-110) | Tuesday, Oct. 29 |
| Texas State | -3.5 (-110) | -166 | U 61.5 (-110) | 7:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| LA Tech | +9.5 (-110) | +260 | O 46.5 (-110) | Tuesday, Oct. 29 |
| Sam Houston | -9.5 (-110) | -339 | U 46.5 (-110) | 8 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Jax State | -1.5 (-110) | -111 | O 63.5 (-110) | Wednesday, Oct. 30 |
| Liberty | +1.5 (-110) | -108 | U 63.5 (-110) | 7 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Kennesaw State | +23.5 (-110) | +1160 | O 52.5 (-110) | Wednesday, Oct. 30 |
| Western KY | -23.5 (-110) | -2800 | U 52.5 (-110) | 7:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Tulane | -15.5 (-110) | -780 | O 55.5 (-110) | Thursday, Oct. 31 |
| Charlotte | +15.5 (-110) | +530 | U 55.5 (-110) | 7:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Georgia State | +7.5 (-110) | +235 | O 49.5 (-110) | Friday, Nov. 1 |
| UConn | -7.5 (-110) | -295 | U 49.5 (-110) | 7 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| South Florida | -2.5 (-110) | -128 | O 52.5 (-110) | Friday, Nov. 1 |
| FAU | +2.5 (-110) | +106 | U 52.5 (-110) | 7:39 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| San Diego State | +23.5 (-110) | +1000 | O 58.5 (-110) | Friday, Nov. 1 |
| Boise State | -23.5 (-110) | -2100 | U 58.5 (-110) | 8 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Ole Miss | -7.5 (-110) | -285 | O 57.5 (-110) | Saturday, Nov. 2 |
| Arkansas | +7.5 (-110) | +230 | U 57.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| North Carolina | -3.5 (-110) | -160 | O 47.5 (-110) | Saturday, Nov. 2 |
| Florida State | +3.5 (-110) | +132 | U 47.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Minnesota | +2.5 (-110) | +106 | O 44.5 (-110) | Saturday, Nov. 2 |
| Illinois | -2.5 (-110) | -128 | U 44.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Duke | +20.5 (-110) | +810 | O 56.5 (-110) | Saturday, Nov. 2 |
| Miami | -20.5 (-110) | -1450 | U 56.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Northwestern | -2.5 (-110) | -128 | O 47.5 (-110) | Saturday, Nov. 2 |
| Purdue | +2.5 (-110) | +106 | U 47.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Stanford | +12.5 (-110) | +385 | O 49.5 (-110) | Saturday, Nov. 2 |
| NC State | -12.5 (-110) | -520 | U 49.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Ohio State | -3.5 (-110) | -160 | O 47.5 (-110) | Saturday, Nov. 2 |
| Penn State | +3.5 (-110) | +132 | U 47.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Indiana | -6.5 (-110) | -245 | O 50.5 (-110) | Saturday, Nov. 2 |
| Michigan State | +6.5 (-110) | +198 | U 50.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Pittsburgh | +6.5 (-110) | +172 | O 62.5 (-110) | Saturday, Nov. 2 |
| SMU | -6.5 (-110) | -210 | U 62.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Wisconsin | +3.5 (-110) | +136 | O 42.5 (-110) | Saturday, Nov. 2 |
| Iowa | -3.5 (-110) | -164 | U 42.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Virginia Tech | -3.5 (-110) | -162 | O 52.5 (-110) | Saturday, Nov. 2 |
| Syracuse | +3.5 (-110) | +134 | U 52.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Vanderbilt | +6.5 (-110) | +190 | O 48.5 (-110) | Saturday, Nov. 2 |
| Auburn | -6.5 (-110) | -235 | U 48.5 (-110) | 12 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Oregon | -13.5 (-110) | -630 | O 47.5 (-110) | Saturday, Nov. 2 |
| Michigan | +13.5 (-110) | +450 | U 47.5 (-110) | 3:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| UCLA | +7.5 (-110) | +240 | O 44.5 (-110) | Saturday, Nov. 2 |
| Nebraska | -7.5 (-110) | -300 | U 44.5 (-110) | 3:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Kansas State | -10.5 (-110) | -430 | O 45.5 (-110) | Saturday, Nov. 2 |
| Houston | +10.5 (-110) | +330 | U 45.5 (-110) | 3:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Arizona | +4.5 (-110) | +150 | O 57.5 (-110) | Saturday, Nov. 2 |
| UCF | -4.5 (-110) | -182 | U 57.5 (-110) | 3:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Texas Tech | +12.5 (-110) | +375 | O 56.5 (-110) | Saturday, Nov. 2 |
| Iowa State | -12.5 (-110) | -500 | U 56.5 (-110) | 3:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Florida | +17.5 (-110) | +570 | O 53.5 (-110) | Saturday, Nov. 2 |
| Georgia | -17.5 (-110) | -850 | U 53.5 (-110) | 3:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Middle Tennessee | +2.5 (-110) | +110 | O 51.5 (-110) | Saturday, Nov. 2 |
| UTEP | -2.5 (-110) | -132 | U 51.5 (-110) | 7 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Arizona State | -1.5 (-105) | -110 | O 56.5 (-110) | Saturday, Nov. 2 |
| OK State | +1.5 (-115) | -110 | U 56.5 (-110) | 7 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| USC | -2.5 (-110) | -126 | O 54.5 (-110) | Saturday, Nov. 2 |
| Washington | +2.5 (-110) | +105 | U 54.5 (-110) | 7:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Kentucky | +15.5 (-110) | +540 | O 44.5 (-110) | Saturday, Nov. 2 |
| Tennessee | -15.5 (-110) | -800 | U 44.5 (-110) | 7:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| Texas A&M | -3.5 (-110) | -166 | O 46.5 (-110) | Saturday, Nov. 2 |
| South Carolina | +3.5 (-110) | +138 | U 46.5 (-110) | 7:30 pm ET |
| Team | Spread | Moneyline | Total | Date/Time |
| TCU | +2.5 (-110) | +106 | O 63.5 (-110) | Saturday, Nov. 2 |
| Baylor | -2.5 (-110) | -128 | U 63.5 (-110) | 8 pm ET |
The Ohio State vs Penn State odds have opened with the 6-1 Buckeyes as 3.5-point road favorites over the 7-0 Nittany Lions.
The biggest spread on the board in Week 10 is Ashton Jeanty’s #17 Boise State Broncos (6-1) laying 23.5 points at home against the San Diego State Aztecs (3-4).
The highest total is 63.5 which is found in two games: Jacksonville State vs Liberty on Wednesday, Oct. 30, and TCU vs Baylor, which is the last kick of the night on Saturday, Nov. 2.
Oregon QB Dillon Gabriel has taken over as the favorite in the 2024 Heisman odds after leading his top-ranked. Ducks to a 38-9 win over #20 Illinois.
Sascha Paruk’s 2024 NCAAF betting record: 11-4 (+5.62 units)
Early NCAAF Week 10 Pick: North Carolina -3.5 (-110) vs Florida State – 1.10 units
It’s a strategy that’s been working all year and I’m not about to abandon it now: fade the Seminoles. No team has failed to meet expectations this year quite like Florida State (1-6, 2-5-1), which went undefeated until bowl season last year and was furious to be left out of the College Football Playoff. But a massive amount of turnover left the Noles looking entirely different in 2024, and it looked like they quit on the season after a Week 0 loss to Georgia Tech in Ireland.
FSU’s latest debacle was a 36-14 drubbing at the hands of rival Miami. The Hurricanes nearly doubled-up the Seminoles in yardage (445 to 248) and held Florida State to just 115 yards through the air on 32 pass attempts.
North Carolina looked like they might be heading down the same road as FSU when they followed a three-game season-opening win streak with a brutal four-game skid. But they exorcised some demons in Week 9 with a 41-14 thumping of a not-terrible Virginia team.
Senior QB Jacoby Criswell had his most-efficient game of the season, going 19-of-30 for 293 yards and two touchdowns as the Heels racked up 431 yards of total offense.
The UNC defense showed a lot more fight than it did during the team’s four-game losing streak, when they allowed an average of 41.5 PPG, including a 70-burger against James Madison. UNC held Virginia under 300 yards, forced two turnovers, and piled up a ludicrous ten sacks.
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Sascha Paruk
Managing Editor
Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.
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