Closing BYU vs Alabama Odds, Score Predictions & Betting Splits for Sweet 16

• The #6 BYU Cougars are underdogs to the #2 Alabama Crimson Tide in the 2025 Sweet 16
• The game total is by far the highest on the board among all eight Sweet 16 games
• Below, see the closing BYU vs Alabama odds plus score predictions for Thursday’s game in Newark

The Sweet 16 starts on Thursday night at the Prudential Center in Newark, NJ, with the #6 BYU Cougars (26-9, 22-13 ATS) facing the #2 Alabama Crimson Tide (27-8, 20-15 ATS) in the East Region semifinal at 7:09 pm ET. The Tide opened as 4.5-point favorites last weekend and the spread has only grown in the last few days, as has the total.

BYU vs Alabama Odds

The BYU vs Alabama point spread is sitting at Tide -5.5 as of Thursday afternoon, up one point from the opening line of Alabama -4.5. The Tide moneyline has also shortened, going from -205 to -223, while BYU’s odds to win straight-up have grown from +170 to +180.

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The game total has also been on the move. After opening at 174.5, which was a full 20 points higher than any other total on the board in the Sweet 16, the O/U has risen one point to 175.5, still with -110 odds each way.

While the analytics agree that BYU/Alabama is going to be the highest-scoring game of the Sweet 16 – by a wide margin – the current upward movement in the total isn’t exactly supported by the projections at KenPom, Haslam, or Torvik.

BYU vs Alabama Score Predictions

All three sites have the total points in the range from 173 to 175, with the margin of victory from Alabama -3 to -5. KenPom has both the lowest total (173) and the biggest margin of victory for the Tide (five points).

Not coincidentally, KenPom also rates BYU far lower than Haslametrics and Torvik. The Cougars are just 24th in overall Net Rating at KenPom, compared to 15th at Haslam and as high as 12th at Torvik.

Alabama is currently the sixth-favorite in the March Madness championship odds at +1800, well ahead of BYU at +7000. Only three of the 16 remaining teams have longer odds: Purdue (+7500), Ole Miss (+7500), and Arkansas (+10000).

Alabama vs BYU Public Betting Splits

The ATS betting splits for BYU vs Alabama are, so far, siding with the Cougars. BYU is getting 58% of ATS wagers and a significant 64% of ATS handle, leaving just 36% of the ATS money on the Tide to cover as 4.5-point favorites.

However, the situation is flipped – to the extreme – when looking at the moneyline splits. Alabama is currently getting 84% of moneyline tickets along with 79% of moneyline handle, which means only 21% of the money is on the Cougars to win straight up.

Unsurprisingly given the line movement, the public is also betting pretty heavily on the over. As of 4:00 pm ET, 66% of game-total wagers and an identical 66% of game-total handle were on over 175.5.