NBA Parlay Picks for Wednesday’s Loaded Slate (+600 Odds)

• Our value NBA Wednesday parlay offers +601 odds for April 2nd action
• This three-leg combo features an underdog spread, a heavy favorite, and promising over bet
• Check our three-leg NBA parlay picks for Wednesday, paying out at +600 odds

Wednesday’s NBA slate presents a perfect opportunity to cash a lucrative parlay. I’ve put together a three-leg combo offering sweet +601 odds that could turn a $100 bet into more than $600 in profit.

My parlay targets value in an underdog spread, a home favorite, and a promising over bet, taking advantage of misconceptions about team strengths as we head into the final stretch. While the public follows the crowd, my breakdown uncovers edges that bookmakers haven’t fully baked into their lines.

Let’s break down each leg of our Wednesday NBA parlay, highlighting the stats and situations that make this combo worth backing as the NBA regular season winds down:

NBA Wednesday Parlay Picks (+601)

With Wednesday giving us a loaded schedule, I’ve zeroed in on three high-value plays that combine for a potential +610 payout. This parlay features a scrappy underdog with matchup edges, a home favorite hitting their stride, and a total that should fly over the number.

Let’s dive into each pick and see why these selections give you the best bang for your buck on Wednesday’s betting card.

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Odds as of April 2, 2025, at DraftKings Sportsbook. Unlock the DraftKings promo code to bet on our Wednesday NBA parlay.

NBA Parlay Pick #1: Spurs +9.5

Kicking off our NBA parlay is the San Antonio Spurs getting 9.5 points against the Denver Nuggets. Everyone’s hammering Denver in the NBA public betting trends, but there are solid reasons to back the visitors with this cushion.

The Spurs (31-44) come into this one trying to snap a five-game losing streak against the Nuggets (47-29) at Ball Arena. While they’ve been struggling lately, San Antonio has been much better against the spread than their record shows. They’ve covered in four of the past six, and are 6-3 ATS overall in their last nine April games.

Denver has flat-out struggled to cover big spreads all season, going just 8-10 against the number when favored by 9+ points. The 2023 champs are winning games but rarely blowing teams out. Our model projection has this as a 5.5 game, giving us plenty of room to breathe with the 9.5-point spread.

The Nuggets’ home-court advantage is legitimate, but they’ve been inconsistent covering big numbers against scrappy teams. In fact, they have just one cover in their past 11 games at Ball Arena. San Antonio’s young roster won’t quit even while trailing, making them dangerous backdoor cover threats until the final buzzer.

NBA Parlay Pick #2: Pacers Spread -15.5

The second leg backs the Indiana Pacers spread against the Charlotte Hornets. While the Pacers are heavy favorites, there’s plenty of reason to feel good about the home team at Gainbridge Fieldhouse.

Charlotte (19-56) limps into Indy having dropped five straight road games, while Indiana (44-31) continues battling for playoff positioning. The talent gap here is massive, with the Pacers boasting multiple All-Star caliber players against a depleted Hornets squad.

Indiana’s offense has been cooking lately, putting up 117.1 points per game (seventh in the NBA). They’ve maintained a positive scoring differential all season and really dominate bottom-tier opponents at home.

The Hornets simply don’t have the firepower to keep up here. With Tyrese Haliburton running the show and finding his groove at the perfect time, the Pacers should control this one from wire to wire. At -108 odds, the Indy spread is solid value as our parlay’s middle leg.

NBA Parlay Pick #3: Pistons/Thunder Over 232

To round out our NBA parlay, I’m backing the Detroit Pistons and Oklahoma City Thunder to go over 232 points in their Wednesday night clash at Paycom Center.

This game showcases one of the league’s premier scorers in Shai Gilgeous-Alexander (32.8 PPG) and his Thunder (63-12) hosting the Pistons (42-33). Tipoff’s set for 9:30 p.m. ET, and while Detroit’s star Cade Cunningham is doubtful with a knee issue, there’s still plenty of scoring punch on both sides to push this total north of the number.

The Thunder have been an absolute scoring machine all season, dropping 120.4 points per game (fourth-best in NBA). Even without Cunningham, the Pistons can still fill it up, sitting 11th in the league offensively (115.5 points per game). Detroit’s secondary scorers like Malik Beasley, Tobias Harris, and Dennis Schroder should get more looks and keep the scoreboard ticking.

Recent trends are screaming over in this matchup. The total has cleared in five of Detroit’s last six games and in six of their last nine road trips. The Pistons have also sailed over in seven of their last nine against Northwest Division squads.

With the Thunder at home and looking to lock down the West’s top seed, expect OKC to push the tempo and light it up. Detroit will have to answer, and without Cunningham’s defensive presence, the Thunder should have an even easier time getting buckets. Take the over to cap off your parlay with confidence.