Chargers vs Cardinals Odds & Picks for MNF (Oct. 21)

• The Los Angeles Chargers visit the Arizona Cardinals on MNF
• The under has hit in 8 of the Los Angeles Chargers last 10 games on the road
• Dive in to the latest Chargers vs Cardinals odds and our predictions below

Justin Herbert and the Los Angeles Chargers travel to Arizona to meet Kyler Murray and the Cardinals in NFL Week 7 MNF action. Jim Harbaugh’s team enter off a win against the Broncos in Denver last week, while the Cardinals were ran off the field in a 34-13 loss at Green Bay. Chargers vs Cardinals kicks off from State Farm Stadium in Glendale, Arizona on Monday, October 21 at 9 pm ET. Catch the second leg of ESPN’s Monday Night Football doubleheader and check out all the Chargers vs Cardinals odds and our best bets, below.

Los Angeles Chargers vs Arizona Cardinals Odds

The Chargers enter MNF as 1.5-point favorites over the Cardinals in the latest NFL odds. While the total for Chargers vs Cardinals is set at 44.5. 

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Chargers Betting News & Notes

Harbaugh’s patented rushing attack has pummeled opponents into submission this season. Led by running back JK Dobbins, the Chargers grind out nearly 130 rushing yards per game. That bodes well against a Cardinals defense that has struggled to stop the run. Quarterback Justin Herbert has played well since injuring his foot in the pre-season. He’s thrown for 815 yards and has done an excellent job protecting the football, with six touchdowns and just one interception.

JK Dobbins is a really fun RB to watch. Watch him reading the LB flow here and cutting back this gap run. https://t.co/qrcKscjWym pic.twitter.com/jtUybhvdEO

— Nate Tice (@Nate_Tice) October 15, 2024

On the flip side, the Chargers defense has been transformed under new coordinator Jesse Minter. Harbaugh bringing Minter with him from Michigan has been a massive success. Los Angeles allow an NFL-low 13.2 points per game, and sit third in EPA per play. Moreover, they’ve surrendered just 0.235 points per play (2nd) and 5.1 yards per play (8th).

Bettors should note, the Los Angeles Chargers are 8-3 (72.7%) against the spread in their last 11 games as a favorite.

Cardinals Betting News & Notes

Arizona’s defensive woes have sunk a once promising season. The Cardinals rank 28th in the NFL in expected points added allowed per play, 29th in EPA per dropback, and are dead last in drop-back success rate. Moreover, Jonathan Gannon’s defense has forced just three punts over the past three games. That’s no surprise to see as the Cardinals surrender 153 rushing yards per game, and sit 27th in opponent rushing success rate.

In huge news on the offensive side of the football, Cardinals receiver Marvin Harrison Jr. has cleared concussion protocol and will play on Monday Night. Murray and Harrison Jr. will need to get on the same page quickly for Arizona to have any hope on Monday night. The rookie has reeled in just 17 of his 37 targets so far.

“I just feel like we’ve got to get them the ball more.”

Arizona Cardinals QB Kyler Murray on getting Marvin Harrison Jr. and playmakers more involved. pic.twitter.com/0fLbbzwJDj

— PHNX Cardinals (@PHNX_Cardinals) October 17, 2024

That being said, it’s not all doom and gloom for Arizona. The Cardinals offense ranks a respectable 13th in expected points added, and success rate. Running back James Conner has rushed for 405 yards and three touchdowns on 4.5 yards per carry.

Be aware, the Cardinals are 1-5 ATS in their last six games at home against the Chargers.

Chargers vs Cardinals Prediction

At the end of the day, the Chargers defense will be the best unit of the field on Sunday. Despite his pedestrian numbers, Justin Herbert remains an elite quarterback. Trust Herbert and the Chargers to get the job done in Arizona against a terrible Cardinals defense. Lay the points.

• Chargers vs Cardinals Pick: Chargers -1.5 (-115)