Week 6 NFL Odds – Opening Betting Lines & Spreads for All Games

• The Chiefs host the Broncos on Thursday Night Football to open NFL Week 6
• The Bills are the biggest NFL Week 6 opening favorite by 14.5 points over the Giants
• A look at all the opening NFL Week 6 odds can be found below with early predictions

NFL Week 6 gets underway when the Denver Broncos visit Taylor Swift and the Kansas City Chiefs in an AFC West showdown on Thursday Night Football.

The Chiefs (4-1) are huge 10.5-point favorites in the NFL odds despite being 0-3 against the spread in their last three meetings with the Broncos. The Broncos (1-4) have allowed an NFL-high 181 points this season.

Sunday Night Football features the Buffalo Bills hosting the New York Giants. The Dallas Cowboys play the Los Angeles Chargers on Monday Night Football in LA.

NFL Week 6 Opening Odds

The Buffalo Bills are NFL Week 6’s biggest opening favorites at 14.5 points over the New York Giants. It’s the second successive week that the Giants are given the longest odds on the NFL board. The smallest spread is the two points that the Falcons are favored by over the Commanders.

The largest over/under is 51.5 points for the Kansas City Chiefs vs the Denver Broncos while the lowest total is 40.5 points for the Ravens vs the Titans.

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Odds as of October 8 at DraftKings. Be sure to claim a DraftKings promo to bet all of the Week 6 NFL action. If you’re a new Kentucky sports bettor, be sure to get your new-customer promo from DraftKings Kentucky as well!

Broncos vs Chiefs Early Odds & Predictions

Straight up, this is anything but a rivalry. Kansas City has won 15 games in a row against Denver. Factor in the betting odds, though, and Broncos vs Chiefs games suddenly become a contest – one that of late is going Denver’s way more often than not.

RUMOR: Taylor Swift to bang the drum at Arrowhead Stadium on Thursday Night Football when the Kansas City Chiefs host the Denver Broncos on week 6 pic.twitter.com/3FWWNemKYI

— Chiefs Kingdom Memes – CKM (@kcchiefsmmz) October 6, 2023

When these two teams clashed in KC last season, Denver was skidding at 1-6 SU through the previous seven games. Favored by 12.5 points, the Chiefs squeaked out a 27-24 victory. The previous meeting in Denver saw the Broncos play host to the Chiefs while in the midst of a four-game slide. As the 9-point road chalk, Kansas City won 34-28.

Overall, Denver is 4-1 ATS in the last five against Kansas City. The Broncos are 3-0 ATS in the last three games in which the Chiefs were the double-digit chalk.

Pick: Broncos +10.5 (-110)

Opening Bills vs Giants Odds & Predictions

Hell has no fury like the Buffalo Bills scorned. Stunned 22-16 by the Aaron Rodgers-less Jets in Week 1, Buffalo followed up by winning and covering in lopsided triumphs over the Raiders, Commanders and Dolphins.

New York Giants fans are not happy!!! pic.twitter.com/5KnksJq0hf

— Big E (@ian693) October 8, 2023

Now the Bills are coming back across the pond following a 25-20 setback to the Jaguars in London, England. And they get to face a woeful 1-4 New York Giants squad on SNF that is 0-6 ATS in their last six games. Buffalo is a 14.5-point pick, but not to worry. The Giants already failed to cover against the 49ers as 10.5-point underdogs. And Giants QB Daniel Jones, who left Sunday’s loss to Miami with a neck injury, is 1-12 SU in prime time games.

Pick: Bills -14.5 (-110)

Expected Week 6 Line Movement

Those who travel for a living will tell you that jet lag hits the worst when you return home. Following two successive victories in games played at England, Jacksonville (3-2) is back home to face Indianapolis (3-2) in a clash for top spot in the AFC South. The Jaguars are set as the 5-point home chalk and are 7-1 ATS in the last eight against the Colts. Might the jet lag factor lead to increased action on the Colts and cause a shortening of the odds on this game?

Pick: Colts +5 (-110)