NFL Week 13 Odds – Opening Betting Lines & Spreads for All Games

• NFL Week 13 begins with the Bills visiting the Patriots on Thursday Night Football.
• The Cowboys are the week’s biggest favorites by 9.5 points over the Colts on Monday Night Football
• A look at all the NFL Week 13 openings odds can be found below with early predictions

Week 13 of the NFL season beings with the Buffalo Bills visiting the New England Patriots on Thursday Night Football, opening as 5.5-point favorites.

Both teams played on the road on Thanksgiving. The Bills beat the Detroit Lions 28-25 and the Patriots lost to the Minnesota Vikings 33-26.

Sunday Night Football features the Dallas Cowboys hosting the Indianapolis Colts. The Tampa Bay Buccaneers host the New Orleans Saints on Monday Night Football. The Cowboys are favored by 9.5 points and the Buccaneers are 5.5-point choices.

The NFL Week 13 odds will be updated throughout the week.

NFL Week 13 Opening Odds

Odds as of November 27th at FanDuel Sportsbook.

At 9.5 points, the Cowboys are the biggest favorites on the board. The Washington Commanders are the slimmest pick at one point over the New York Giants.

The highest total is 51.5 points for the Kansas City Chiefs-Cincinnati Bengals game. Saints vs Buccaneers has the lowest over/under at 39.5 points.

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Bills vs Patriots Early Odds & Prediction

The Bills (8-3) have won back-to-back games following consecutive losses while the Patriots (6-5) had their three-game winning streak ended by the Vikings.

Tyler Bass’ 45-yard field goal with two seconds left gave the Bills the win over the Lions. Josh Allen set up the winning kick with a 36-yard pass to Stefon Diggs and two rushes for 12 yards.

Allen passed for 253 yards and added 78 yards rushing.

"I have the best quarterback in the league."

Stefon Diggs, Tyler Bass and Josh Allen celebrate a nail-biting Thanksgiving W with @tracywolfson, and turkey legs of course 🍗 pic.twitter.com/p23AhaeYEl

— NFL on CBS 🏈 (@NFLonCBS) November 24, 2022

Mac Jones passed for a career-high 382 yards and two touchdowns, but it wasn’t enough to get the Patriots past the Vikings. New England’s offense stalled in the fourth quarter with two three-and-out punts and a turnover on downs.

Jones’ performance on Thanksgiving was quite encouraging, though. Considering the Bills have plenty of injuries on defense, the Patriots look like a live home underdog.

Pick: Patriots +5.5 (-110)

Chiefs vs Bengals Early Odds & Prediction

In a rematch of last season’s AFC Championship Game, the Chiefs are three-point favorites.

The Chiefs (9-2) ran their winning streak to five games Sunday by beating the injury-depleted Los Angeles Rams 26-10 on the road despite a listless performance.

Patrick Mahomes threw for 320 yards and a touchdown. Rookie Isiah Pacheco had a rushing TD as part of a 69-yard performance.

Guess who? 😏

📺: #LARvsKC on FOX pic.twitter.com/fSYL1pkCfJ

— Kansas City Chiefs (@Chiefs) November 27, 2022

The Bengals (7-4) beat the Tennessee Titans 20-16 on Sunday on the road for their third straight win and fifth in the last six games. Joe Burrow’s 27-yard touchdown to Tee Higgins with 13:42 remaining held up as the game-winning score.

Burrow threw for 270 yards. Higgins had 114 yards on seven receptions.

Despite the Chiefs having the revenge angle, the Bengals are playing well are also live home dogs.

Pick: Bengals +3 (-110)

Seahawks vs Rams Early Odds & Prediction

The Rams (3-8) are reeling as their five-game losing streak matches the longest by a defending Super Bowl champion. Quarterback Matthew Stafford missed Sunday’s loss to the Chiefs because of a concussion.

Thus, the Seattle Seahawks have been installed as 4.5-point road favorites. However, the Seahawks (6-5) have lost back-to-back games, including to the Las Vegas Raiders 40-34 in overtime Sunday at home, following a four-game winning streak.

This line just doesn’t feel right despite the Rams’ struggles. Let’s stick with the live home underdog theme.

Pick: Rams +4.5 (-110)