NFL Week 8 Picks Straight Up – Predicted Upsets and Underdogs Showing Value

By Daniel Coyle in NFL Football
Published:

- Stout Broncos defense poised to spoil Jags’ London party
- Hobbled Seahawks receiver corps faces tough task against stingy Giants pass defense
- Read on for this week’s bets bets to pull off upsets
We got back on track last week, padding our stack by 1.92 units with two of our three picks coming through, as Seattle knocked off the Los Angeles Chargers and the New York Jets topping Denver.
The Seahawks and the Broncos make their way back into our upset list this week, but this time joining San Francisco as the three favorites to fade. So read on to get the scoop on all our NFL Week 8 upset picks.
NFL Week 8 Upset Picks
Matchup | Spread | Moneyline | Pick | Units |
---|---|---|---|---|
Denver Broncos vs Jacksonville Jaguars | JAX -2.5 | +118 | Broncos | 1 |
New York Giants vs Seattle Seahawks | SEA -3 | +140 | Giants | 1 |
San Francisco 49ers vs Los Angeles Rams | SF -1.5 | +105 | Rams | 1 |
Odds as of October 28th at Caesars Sportsbook.
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Broncos Defense Up to the Task
Now riding a four-game losing streak in the wake of last week’s 16-9 loss to the Jets, the Broncos rank dead last in the league with just 14.3 points scored per game. Matters have not been helped by the hamstring injury that kept quarterback Russell Wilson out of last week’s game.
For a second straight day, Broncos’ QB Russell Wilson was listed as being a limited participant at practice due to his hamstring injury. Wilson has said he intends to play Sunday in London vs. the Jaguars in the game that will be aired on ESPN+.
— Adam Schefter (@AdamSchefter) October 27, 2022
While the Broncos’ woes are shocking, they are equaled, if not surpassed by those of the Jaguars, who get set for their annual London pilgrimage also riding a four-game slide. Jacksonville is coming off a heartbreaking 23-17 loss to the New York Giants, and have seen each of their past four defeats all come by just a single score.
Time for your weekly installment of The #Broncos Defense Is Really Freaking Good:
• 1st in red zone percentage
• 1st in yards per play
• 2nd in yards per game
• 2nd in passing yards per game
• 3rd in points per game
• T-3rd in sacks
• 5th in third down percentage— Zack Kelberman (@KelbermanNFL) October 28, 2022
The Jaguars have seized the early lead in each game on their 0-4 run, and have managed to power their attack with three straight impressive backfield performances from Travis Etienne.
A fast start would serve them well against the offensively-challenged Broncos, regardless of whether Russell Wilson sees action. However, the Jags will face a stiff challenge from a stout Broncos rush defense that has allowed just one score over the past three games, and just four TDs all season, while forcing four fumbles.
If you’ve followed me for a while you would know Trevor Lawrence is my guy. But lets be honest here.
If Justin Fields did this with 42 seconds left down 6 points, the Media would be screaming “bust” and would be clowning the Bears in every way imaginable pic.twitter.com/YTqiJ6KHVq— Sadeek 🪐 (@SadeekNextWave) October 25, 2022
That adds to the already enormous pressure on Trevor Lawrence as he leads the Jags into Wembley Stadium on Sunday morning as 2.5-point favorites. The Jacksonville pivot has tossed for just one score and two picks over the past three games, and leads an offense that has averaged a meager 3.3 points in the fourth quarter over the past four games.
Giants Defense Poised to Feast on Hobbled Seattle Receivers
One of the most intriguing matchups of Week 8 features two of the season’s most surprising teams, as the Seattle Seahawks host the New York Giants as 3-point favorites in the NFL odds. Riding high following last week’s 37-23 rout of the Chargers, the Seahawks return home as betting favorites.
Geno Smith led the #Seahawks to a 37-23 victory against the LA Chargers today, the only team Russell Wilson never beat as a starter in Seattle. Smith, Walker, and a great defensive gameplan has Seattle at 4-3 and in 1st in the NFC West! #GoHawks pic.twitter.com/xErj6iQL0n
— Toby Srebnik (he/him) (@fsutoby) October 23, 2022
With Geno Smith guiding the offense, the Seahawks have scored at least 32 points three team over their past four games, and Smith now sits near the top of league quarterback stats in an array of categories during his rise to candidate for NFL Comeback Player of the Year honors.
But engaging in the type of run-and-gun play that proved effective to varying degrees against the Chargers, New Orleans, and Detroit will be far tougher to pull off against the resurgent Giants. That is particularly true given Seahawks receivers Penny Hart, DK Metcalf, and Tyler Lockett all missed time at practice this week due to injuries,
The Seahawks list WRs DK Metcalf and Tyler Lockett as questionable for Sunday's game vs. the Giants. Five others also questionable: OLB Darrell Taylor, DT Poona Ford, RG Gabe Jackson, G Phil Haynes and CB Sidney Jones IV.
LB Nick Bellore is out and WR Penny Hart is doubtful.
— Brady Henderson (@BradyHenderson) October 28, 2022
New York survived a late rally to eke out a narrow 23-17 win in Jacksonville to improve their SU record to 6-1 on the season. The Giants have been surprisingly effective at containing some of the passers in the game during their 4-0 run, including Aaron Rodgers and Lamar Jackson.
And last week, it was Trevor Lawrence’s turn. After keeping the Jags passer out of the end zone, the Giants have now allowed just three TD passes while making three picks over four games.
You don't see this very often with a Giants quarterback:
Daniel Jones is the NFC Offensive Player of the Week.
He passed for 202 yards and ran for a career-high 107 yards in Jacksonville.
And, oh yeah, he led the Giants to another fourth quarter comeback victory.— Paul Schwartz (@NYPost_Schwartz) October 26, 2022
More important has been the resilience of the Giants’ offense, which has been susceptible to slow starts, but which has outscore opponents by a wide 41-9 margin in fourth quarter action during the win streak.

Healthy Rams Come off Bye Seeking Vengeance
Fresh off a brutal 44-23 defeat at the hands of the Kansas City Chiefs, the San Francisco 49ers have emerged as slim 1.5-point road favorites in this weekend’s date with the Los Angeles Rams. San Francisco rolled to a 24-9 home win over the Rams in Week 4.
49ers status vs Rams
OUT
WR Deebo Samuel
LB Dre Greenlaw
FB Kyle Juszczyk
DT Arik Armstead
Questionable
WR Jennings
CB Verrett
KS on Deebo: "Not a precaution. He’s not good enough to go. The fact even had chance hopefully he’ll be good with a week off & be ready for next game"— Cam Inman (@CamInman) October 28, 2022
However, with the team facing injury woes on both sides of the ball, including receivers Deebo Samuel and defenders Arik Armstead and Dre Greenlaw, duplicating that feat will be a challenge.
LA Rams 24-10 Panthers 🏆
Ben Skowronek and Darrell Henderson's touchdowns in the second half helped the Rams defeat the Carolina Panthers 24-10 despite their offensive struggles in the first half 🐏 #BlockSports #NFLTwitter #RamsHouse #Panthers pic.twitter.com/Jp0pwoq0N3
— BlockSports (@BlockSportsintl) October 16, 2022
The Rams entered last week’s bye on a high after a 24-10 demolition of the Carolina Panthers, in which they limited to just 203 total yards. The win was particularly welcome after the team was embarrassed in consecutive losses to the Niners and Dallas.
However, the Niners’ current health concerns make it less likely they can match the ferocious defensive performances the well-rested and largely healthy Rams faced in their two recent losses.

Sports Writer
Daniel has been writing about sports and sports betting for over 23 years. The seasoned pro has contributed to the likes of Sports Illustrated, Sportsnet, NESN, Bleacher Report, OddsShark, the Globe and Mail, and The Nation magazine.