Champions League Odds & Picks – RB Leipzig vs Real Madrid, Napoli v Rangers & More

• Matchday 5 of the Champions League takes place across Tuesday and Wednesday this week
• Several teams are fighting to stay in the competition, while a raft of others can confirm their place in the last 16
• Read below for Champions League odds & picks for October, 25 and 26

With four of six group stage matches played, the stakes are high in the Champions League. Some of the biggest clubs in Champions League odds are in must-win territory, with Barcelona, Atletico Madrid and Juventus all in desperate need of victories. Something to consider in your Champions League picks. A few sides have already confirmed their berth in the knockouts next year, and others could join them this week.

Erling Haaland returns to Germany to face his former team Borussia Dortmund with Manchester City knowing a win will guarantee top spot in the group. Tottenham are looking to bounce back from some poor results at home to Sporting, while Juventus are in Portugal for a pivotal game with Benfica.

Champions League Odds Matchday 5

Odds as of Oct 24 at Barstool Sportsbook. Use this Barstool Sportsbook promo code to bet on this week’s Champions League fixtures

Paris Saint Germain are the biggest favorites for Matchday 5, with a -1000 moneyline price for the visit of Maccabi Haifa. Viktoria Plzen are the biggest outsiders with a price of +2500 for their trip to San Siro to face Inter. A tight-fought match is expected between Barcelona and Bayern, and the same goes for Real Madrid’s trip to face Leipzig.

Goals are likely for Manchester City’s clash with Dortmund, where it is just +128 for over 3.5 goals. It is also +123 for over 3.5 between Ajax and Liverpool.

RB Leipzig vs Real Madrid Prediction

RB Leipzig still has a shot at top spot in Group F after Real Madrid’s draw with Shakhtar Donetsk last time out. The hosts could also drop out of the top two if they fail to win, however, with Shakhtar facing Celtic. Significantly, Los Blancos are without Luka Modric, Karim Benzema and Federico Valverde for this fixture, which contributes to their longer odds.

It's a Real Madrid thing 👑 pic.twitter.com/jzi6PZZwre

— GOAL (@goal) October 22, 2022

Leipzig made a dramatic late comeback against Augsburg at the weekend but still had to share the spoils. Outside the Champions League spots in the Bundesliga, they are having a difficult start to the season, while Real are unbeaten so far in 2022-23. The visitors are less dangerous without Ballon d’Or winner Benzema, but their midfield remains formidable even with Modric and Valverde sidelined.

📊| Since the start of last season, no LaLiga player has made more assists than Vinícius Junior in all competitions (20). 🇧🇷💫 pic.twitter.com/DItLpAsEvC

— Real Madrid News (@onlyrmcfnews) October 23, 2022

While the home team can be tough to break down and only lost 2-0 at the Santiago Bernabeu, they have now conceded five in three matches. It will be a competitive match, but there’s value in backing Real to take all three points and guarantee they win the group.

Pick: Real Madrid Moneyline (+145)

Inter vs Viktoria Plzen Prediction

Drawn into the group of death, Viktoria Plzen have lost all of their matches so far, shipping 16 goals in the process. They were more competitive in the group stage of 2018-19, including a win over Roma, but this competition has generally been very challenging for the Czech side. Inter are the hosts on this occasion with seven points from their last three Champions League matches.

The Nerazzurri won 2-0 away to Viktoria Plzen on Matchday 2, with over 70% of possession and goals in each half. Michal Bílek’s side had 11 fewer shots and played most of the second half with 10 men. Since that match, they have lost 5-0 and 4-2 to Bayern Munich.

Smiles all around in the @Inter_en camp after a 𝘷𝘦𝘳𝘺 𝘷𝘢𝘭𝘶𝘢𝘣𝘭𝘦 away win 😀😀😀#FiorentinaInter pic.twitter.com/IrEVI7k9wu

— Lega Serie A (@SerieA_EN) October 23, 2022

Inter played out a seven-goal thriller with Fiorentina, ending in a 4-3 win, at the weekend. In their last home match, they won both halves against Salernitana. With the hosts at such a short price to take all three points, winning both halves is a good value bet here. This is going to be one-way traffic, and Plzen’s defense clearly cannot cope with the quality of opposition in the Champions League.

Pick: Inter to win both halves (+102)

Napoli vs Rangers Prediction

Rangers have lost all four of their Champions League matches, conceding 16 and scoring just once. They were hammered 3-0 by Napoli at Ibrox on Matchday 2, and have their work cut out to avoid a thrashing when they head to Naples this week.

Napoli are on fire this season 🔥 pic.twitter.com/C7efHxMdoD

— ESPN FC (@ESPNFC) October 24, 2022

Napoli have scored 17 in four Champions League fixtures, and are riding an 11-match winning streak in all competitions. They are Europe’s form team — the last time they failed to win was in August.

Prior to their 1-0 over Roma last time out, they had scored three or more goals in five consecutive fixtures. They have scored over 2.5 in all of their Champions League fixtures, and their 14.4 expected goals in the competition is the most by a large margin.

Much like Plzen, Rangers were given a tricky draw and have been completely overwhelmed. That trend will surely continue against a Napoli team absolutely brimming with confidence.

Pick: Napoli to win and score over 2.5 goals (-110)