Seahawks vs 49ers Odds, Betting Lines, and Picks for Week 2 of NFL Season

• The San Francisco 49ers are heavy home favorites against the Seattle Seahawks Sunday, September 18th
• The Seahawks are coming off an impressive win over the Broncos, while the 49ers were upset by Chicago
• See the Seahawks vs 49ers picks and odds ahead of their Week 2 tilt, along with our prediction below

The Seattle Seahawks and San Francisco 49ers were expected to be headed in totally different directions this season.

After the two teams clash Sunday, potentially it’ll be Seattle going 2-and-0, and the 49ers 0-2, which nobody expected.

Having said that, San Fran has a big leg up in the eyes of oddsmakers as they host their NFC West rivals at Levi’s Stadium as 9-point favorites when things kick off at 4:05pm ET on Sunday, September 18th. The game will air on FOX.

Seahawks vs 49ers Odds

Odds as of September 17th. Be sure to check out this unique Barstool Sportsbook promo code to bet on the NFL this weekend.

According to the Week 2 NFL Betting Trends, 81% of the bets are actually on the underdog Seahawks to cover the spread. 59% of the bets are on Kyle Shanahan and co. to win outright, however.

Points aren’t expected to come in droves on Sunday, with the total set at 40.5.

Just like their Week 1 contest that saw a lot of rain in Chicago, there’s a 60% chance of rain in the 49ers home opener along with wind gusts over 20 miles per hour. Temperatures are expected to be around 70 degrees at game time.

Seahawks Betting Outlook

In the first half of the Seahawks’ 17-16 stunning Monday Night Football victory over the Broncos, Geno Smith did his best Russell Wilson impression, slicing and dicing Denver’s D to the tune of completing 17-of-18 passes for 164 yards and two TD’s.

Geno Smith passer rating, last four games:
vs. DEN 119.5
vs. JAX 128.5
vs. NO 94.3
at PIT 99.6

Six TDs, 0 INTs#Seahawks

— Aaron Levine (@AaronLevine_) September 16, 2022

Seattle’s young offensive line held up relatively well, as they were just the third team in the last 50 years to start a pair of bookend offensive tackles (Charles Cross and Abraham Lucas) in Week 1. Smith was relatively clean in the pocket, getting sacked just twice.

Smith distributed the ball well to seven different receivers, and got his tight ends involved, with both Will Dissly and Colby Parkinson snagging TD’s. The Hawks will also be getting reinforcements returning in a pair of offensive players.

Per Carroll, Ken Walker III and Damien Lewis will both be good to go for Sunday. Shelby Harris also returned to practice

— Corbin K. Smith (@CorbinSmithNFL) September 16, 2022

Pete Carroll is known to prefer a ground and pound style, yet Rashaad Penny only rushed twelve times (for 60 yards) in Week 1. With rookie second-rounder Ken Walker III good to go (hernia), expect more of a run-heavy affair.

Seattle has a relatively clean bill of health, minus star safety Jamal Adams being placed on injured reserve. Slot cornerback Justin Coleman (calf), may not be able to go, which would likely thrust rookie fourth-round pick Coby Bryant into action.

49ers Betting Outlook

It’s hard to fully gauge how the Trey Lance era at quarterback will go, based on the sloppy field conditions at Soldier Field last weekend. Nevertheless, the 2021 third overall pick wasn’t lighting the world on fire, going 13-for-28 for 164 yards, no TD’s, one INT and 13 carries for 54 yards.

Trey Lance is 22. When Josh Allen was 22 he completed 53% of his throws and had more picks than TDs in his first NFL season. When Pat Mahomes was 22 he wasn't even starting. Even the best QBs in the league right now were question marks at that point in their careers.

— Chris Biderman (@ChrisBiderman) September 15, 2022

A massive weapon could be returning to aid in his Week 2 affair with the bitter rival Seahawks, as George Kittle (groin), is listed as questionable. The 49ers star tight end didn’t play in week 1, which led to the Niners other TE’s (Ross Dwelley and Tyler Kroft) accounting for just two catches for 20 yards.

With running back Elijah Mitchell going down for two months (sprained MCL) expect even more Deebo Samuel. He rushed it eight times for 52 yards and a TD in Week 1, and caught just two passes for 14 yards.

Even without Mike McDaniel, the #49ers’ run game was still creative.

49ers in 11 personnel against 3 DBs. Motion Deebo Samuel back into a split-back formation (running against a lighter box).

Watch what the fake to Samuel does to the defense, this is stealing 9 yards.. pic.twitter.com/FaURgWmgsM

— Akash Anavarathan (@akashanav) September 16, 2022

San Fran doesn’t have a slew of other injuries that will prevent them from competing hard, which is reflected by the rather generous nine-point spread.

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Seahawks vs 49ers Pick

Since Kyle Shanahan became Head Coach of the 49ers, Pete Carroll has been his bugaboo. In ten meetings, the Seahawks veteran coach has gotten the better of Shanahan eight times.

In three of the last four instances, the ‘Hawks won by a touchdown or more – of course, that was with Russell Wilson at the helm.

Pete Carroll’s defense always gives Kyle Shanahan fits. Shanahan is 2-8 against him.

Going to be another dogfight on Sunday. Seattle’s defense looks fast and physical tonight. #Seahawks #FTTB #49ers

— Chase Senior (@Chase_Senior) September 13, 2022

While it’s not realistic to expect Geno Smith to suddenly turn into a Hall of Famer overnight and play like he did in the first half against Denver, he’ll be able to keep the game close. The 49ers are playing in their own barn and went to the NFC title game a year ago. They should win, but Seattle can absolutely keep it close and cover the points.

The Pick: Seahawks +9 (-110); 2 units to win 1.82 units

Record: 1-1; Overall for -0.08 units