White Sox vs Guardians Odds, Lines & Spread (Aug 21)

By Blair Johnson in MLB Baseball
Published:

- The Chicago White Sox and Cleveland Guardians face off at Progressive Field on Sunday, August 21st
- The Pale Hose have battled their back into the AL Central race, while the Guardians sit atop baseball’s tightest division race
- Read below for the White Sox vs Guardians odds and betting preview
The Chicago White Sox (62-59) face the Cleveland Guardians (64-56) on Sunday at Progressive Field in the finale of a three-game series between the division foes that has a scheduled first pitch of 12:05 pm ET.
Tony La Russa’s club will send Dylan Cease to the mound, while Terry Francona’s group counters with Aaron Civale.
White Sox vs Guardians Odds
Team | Runline | Moneyline | Total |
---|---|---|---|
Chicago White Sox | -1.5 (+140) | -130 | Ov 7.5 (-115) |
Cleveland Guardians | +1.5 (-165) | +110 | Un 7.5 (-105) |
Odds as of August 20 at Caesars Sportsbook. Get Caesars Sportsbook bonus code.

Chicago vs Cleveland Probable Pitchers
The 26-year-old Cease is coming off a start in one of the marquee pitching matchups of the season, when he went head-to-head with Justin Verlander. The White Sox ultimately prevailed over the Astros by a score of 4-3, with neither pitcher factoring in the decision.
Cease went five innings against Houston on Tuesday, allowing six hits, three earned runs and three walks while striking out four.
Dylan Cease is on a roll!
He now has the 3rd-lowest ERA in MLB.
(MLB x @XboxGamePass) pic.twitter.com/WzyvESWzXT
— MLB (@MLB) August 16, 2022
The Pale Hose are 18-6 in Cease’s starts — with 11 of those being of the quality variety. An even more impressive 10 of those outings have been scoreless.
Meantime, Civale hasn’t been quite as stellar in 2022 as he was last season — when he went 12-5 with a 3.84 ERA over 124.1 innings — but that’s because he hasn’t been healthy.
The 27-year-old has had two different month-long stints on the injured list, the first due to a strained glute and the second because of a sprained wrist. Since his return though, Cleveland is 2-0 when he gets the ball.
Aaron Civale's Beautiful Curveballs. 😍
7Ks on Curveballs. pic.twitter.com/MSxpTOCU7s
— Rob Friedman (@PitchingNinja) August 15, 2022
Civale went six innings against the Tigers on Monday in his most recent start, allowing only three hits, an earned run and a walk while striking out 10 in an eventual 4-1 victory.
Cease vs Civale Stats
12-5 | Record | 2-5 |
2.09 | ERA | 5.63 |
2.69 | xERA | 4.27 |
32.3% | K% | 23.7% |
The ageless Johnny Cueto helped the Pale Hose bounce back on Saturday after a disappointing series opener against the Guardians.
The ChiSox blew a 2-1 lead in the seventh inning on Friday, but Cueto went 8.1 scoreless innings as La Russa’s group evened the series 2-0. Jose Abreu had a big RBI double in the win.
José Abreu's double to dead center *just* avoided bouncing over the fence, allowing Luis Robert to score from first after his leadoff single. White Sox lead 1-0 in the sixth. The dugout is amped
— James Fegan (@JRFegan) August 21, 2022
The White Sox are now 6-3 over the last nine games and, despite being in third place in the division, have the shorter odds than Cleveland and Minnesota to win the World Series.
Meantime, Cleveland has gone 18-11 since the break and has a -game lead over Minnesota in the AL Central entering Sunday’s play. A huge part of the team’s success all season has been Jose Ramirez.
The All-Star third baseman launched his 23rd homer and drove in his 99th RBI of the season in the Guardians’ 5-2 comeback win on Friday in the series opener.
Jose Ramirez is already a thorn on the side of the #WhiteSox. Jose is going to be around for a long time. 😭 #CWSvsCLE #MLB #ChangeTheGame #SouthSideOrDie #SoxSide #SoxPride pic.twitter.com/XOSaXixyoX
— ͏Sidney Brown (@sidkid80) August 21, 2022
In addition to Ramirez, Josh Naylor and Andres Gimenez are the other Guardians with double-digit home runs.
The Guardians currently have +7000 odds to win the Fall Classic, while the White Sox are at +4700 in the World Series odds.
CWS vs CLE Last 10 Meetings
Date | Home Team | Away Team | Score |
---|---|---|---|
8/20/22 | Guardians | White Sox | CWS, 2-0 |
8/19/22 | Guardians | White Sox | CLE, 5-2 |
7/24/22 | White Sox | Guardians | CWS, 6-3 |
7/23/22 | White Sox | Guardians | CWS, 5-4 |
7/23/22 | White Sox | Guardians | CLE- 7-4 |
7/22/22 | White Sox | Guardians | CLE, 8-2 |
7/13/22 | Guardians | White Sox | CWS, 2-1 |
7/12/22 | Guardians | White Sox | CWS, 7-0 |
7/12/22 | Guardians | White Sox | CLE, 4-1 |
7/11/22 | Guardians | White Sox | CLE, 8-4 |
White Sox vs Guardians Prediction
While he may not be a true workhorse just yet, Cease has emerged as the best pitcher in the Windy City. With Cueto falling just short of a complete game shutout on Saturday, look for the young buck to motivated by the crafty veteran.
Cleveland has a dangerous offense. Ramirez was getting early AL MVP consideration before Aaron Judge exploded. But I’m not sure if the Guardians have enough firepower to get past the White Sox.
Pick: White Sox (ML -130)
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Sports Writer
Blair Johnson is a veteran journalist and seasoned sports content creator. He has been writing and producing content as long as he can remember, with such familiar names as CNN, NFL Media and Yahoo. Blair currently lives and works in the greater Los Angeles area.