French Open Men’s Singles Round of 16 Odds & Picks (May 30)

• One of the eight players in action Monday at the French Open will be in the singles final on Sunday
• No. 4 seed Stefanos Tsitsipas, the biggest favorite among then, has a tricky match vs teenager Holger Rune
• Read on as we break down Monday’s matchups, and make some predictions

The three favorites to win this year’s French Open are in the top half of the draw, and one will be eliminated on Tuesday when Novak Djokovic meets Rafael Nadal in the quarterfinals.

In the bottom half, No. 4 seed Stefanos Tsitsipas was behind the “big 3” at +400 before the tournament began.

French Open Men’s Round of 16 Odds

Odds as of May 29 at Caesars Sportsbook

Since then, Tsitsipas’s odds have dropped to +600 as betting on the French Open winner continues.

And No. 2 seed Daniil Medvedev, who has had surprisingly few issues through his first three rounds, has seen his odds to win it rise from +5000 to +1600.

He’s still a major longshot, though.

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Rublev vs Sinner Prediction

Jannik Sinner leads Andrey Rublev 2-1 in their head-to-head. And he has won both of their meetings on red clay.

The one match he did lose, Sinner retired after three games in a match in Vienna in 2020.

And yet, Rublev is the slight favorite.

But it’s not a big secret, even though Sinner doesn’t want to go into details, that he’s not 100% physically.

He admitted as much after his third-round victory over Mackenzie McDonald, whom he said also wasn’t 100%.

Sinner had a wide wrap underneath his left knee cap in that match. And when he wasn’t sprinting for a ball, he was visibly limping pretty much the whole match.

It’s unlikely that two days will make a significant difference there. And Rublev – with a few ups and downs – has played well enough that you’d expect him to win it.

He has enough pure power to make Sinner chase from side to side. That’s something the young Italian won’t be looking forward to doing.

He may have hit the end of his French Open road for this year.

Pick: Rublev in Four Sets (+370)

Cilic vs Medvedev Prediction

There aren’t many players in the field who actually have Grand Slam titles. But Marin Cilic is one of them, even if it was ages ago, back in 2014 at the US Open.

He’s a dark horse for some, to win the whole thing.

Medvedev is 3-0 against him, although he’s played him indoors on hard, outdoors on a hot and humid hard court in Washington, DC, and on grass at Wimbledon last year, where he came back from two-sets-to-none down to win in five.

This is their first meeting on clay.

How to start your Saturday with @DaniilMedwed 🏃#RolandGarros pic.twitter.com/LOUjIb0ZhB

— Roland-Garros (@rolandgarros) May 28, 2022

Medvedev will have belief. And given the Russian played just one match the entire clay season, he’s not match tough. But he’s also fresh.

Cilic has rolled to the round of 16 with the loss of just one set. But he’s also had a super draw – no one who would have been expected to trouble him.

The Croat may take a set, but we’re picking Medvedev to get through this, and go on to face Rublev in the quarterfinals.

Pick: Medvedev in Four sets (+290)

Rune vs Tsitsipas Prediction

If Tsitsipas could be pushed to his limits by players like Lorenzo Musetti and qualifier Zdenek Kolar, there’s no reason to think Rune won’t give him all kinds of trouble.

While the No. 4 seed righted the ship with an easy victory over Sweden’s Mikael Ymer in the third round, it doesn’t feel like he’s out of the woods in the least.

There’s definitely some ennui, some pressure as he knows he’s the guy who should make the final out of the bottom half.

Stef's frustration and well, 'happiness' after his win. I do (and did) feel for him.. Let's go on Saturday for a drama-free victory!❤️🥰💪 #tsitsipas #RolandGarros2022 pic.twitter.com/YJ6q0EiDFp

— Tsitsipetra (@Tsitsipetra1) May 27, 2022

Meanwhile, Rune, just turned 19, has all the enthusiasm of a brand-new puppy. And if his issues in the longer matches have been situations where he has cramped, the very cool weather in Paris in this early part of the second week should ease those concerns.

He has little to lose – already in the second week and 21-4 so far during this clay-court swing. He will give Tsitsipas a tussle.

Pick: Rune and 6.5 games (+100)

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