Real Madrid vs Manchester City Odds & Prediction – Champions League Semifinals Leg 2

By Sam Cox in Soccer News
Published:

- Real Madrid host Manchester City at Santiago Bernabeu on May, 4th
- Manchester City carry a 4-3 aggregate lead from the first leg and are +105 favorites on the moneyline
- Read below for the latest Real Madrid vs Manchester City odds and our prediction
Real Madrid vs Manchester City matchup at the Santiago Bernabeu on May, 4th with a place in the Champions League final on the line. City, long-time favorites in Champions League odds, have a 4-3 advantage heading into the second leg after an all-time classic at the Etihad Stadium.
Los Blancos wrapped up the La Liga title at the weekend following the first leg thriller. Their home form is generally strong this term, but they lost to Chelsea at the Bernabeu in the last round and fell 4-0 to Barcelona at home just a few weeks ago.
Real Madrid vs Manchester City Odds
Matchup | Moneyline |
---|---|
Real Madrid | +230 |
Manchester City | +105 |
Draw | +295 |
Odds as of May 3 at Barstool
Over/Under and Spread
A look at Asian Handicaps & pointspreads shows Manchester City are narrow favorites for this one with Pep Guardiola’s team priced at +104 on the -0.5 hanidcap. After an entertaining first leg, the over/under is set at 3.5 with the over at +130.

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Real Madrid vs Manchester City Prediction for Semifinal Leg 2
Manchester City dominated most of the first leg, and were left wondering how they only have a one-goal advantage as the tie heads to Madrid. City had 2.8 expected goals to under 1.5 for the away side, but Real did enough to give themselves a fighting chance in the second leg. Carlo Ancelotti’s team are still out at +335 to progress.
xG map for Manchester City – Real Madrid
fantastic City performance and, you know, football happened pic.twitter.com/Xp8vFrGpyZ
— Caley Graphics (@Caley_graphics) April 26, 2022
Both teams are coming off emphatic 4-0 wins at the weekend, with Real seeing off Espanyol and Manchester City hammering Leeds at Elland Road. Including the first leg, it’s four straight wins for Pep Guardiola’s side with 16 goals scored in the process. It’s touch and go between City and Liverpool to be considered the best side in the world right now, though it would be foolish to write off such an experienced Real side, particularly after their dramatic home leg against Chelsea.
No player in this City team has won the Champions League. It’s a trophy that has eluded Guardiola since he left Barcelona, with the Spaniard often tripping himself up with misguided tactical decisions. Ancelotti is a master of the competition and he boasts a squad packed with Champions League winners. In Karim Benzema, Real arguably have the best player in the world leading their attack alongside the always dangerous Vincius Junior, who tormented Chelsea over two legs.
Real Madrid vs Manchester City Champions League Statistics
WLWWLL | Form | LWDWDW |
25 | Goals scored | 28 |
51.9% | Average possession | 61.1% |
21 yellows, 0 reds | Cards | 19 yellows, 1 red |
16.1 | Shots per match | 14.9 |
16.6 | Non-penalty expected goals | 20.9 |
Real Madrid vs Manchester City Lineups And Injuries
Real Madrid Projected Lineup: Thibaut Courtois; Dani Carvajal, Nacho Fernandez, Eder Militao, Ferland Mendy; Luka Modric, Casemiro, Toni Kroos; Federico Valverde, Karim Benzema, Vinicius Junior.
Real Madrid Injuries: David Alaba, Eden Hazard.
Manchester City Projected Lineup: Ederson; Kyle Walker, Ruben Dias, Aymeric Laporte, Joao Cancelo; Kevin De Bruyne, Rodri, Bernardo Silva; Riyad Mahrez, Gabriel Jesus, Phil Foden.
Manchester City Injuries: John Stones.
Real Madrid vs Manchester City Best Bet
This should be another brilliant game for the neutral. City are clearly the better team, and are rightly favored to win on the night, but there will be plenty of entertainment along the way. Where City missed numerous clear chances in the first leg, Real were clinical, and they will need to be every bit as ruthless if they are to overturn this deficit under the lights on Wednesday.
🇫🇷 Karim Benzema – 42 goals & 13 assists
🇧🇷 Vinicius Jr. – 18 goals & 14 assistsOne of the best attacking duos in world football this season 👏 pic.twitter.com/sq4ZPnNs51
— ESPN FC (@ESPNFC) April 30, 2022
Just as was the case in the first leg, City will have the majority of possession. Real were overrun at times in midfield with Toni Kroos and Luka Modric struggling against the younger legs of their opponents. Benzema and Vinicius only need a couple of chances, though, and they will get plenty of opportunities in transition.
Real will need to be relatively aggressive given the deficit, however. This has the makings of an end-to-end match once again, and another high-scoring affair is likely. City should have enough to get the win on the night, but Real will make them work for it.
Pick: Manchester City Moneyline & Over 2.5 Total Goals (+170)
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Sports Writer
Sam Cox is a freelance writer and sports junkie, who has spent the past several years immersed in the online gaming industry. He has worked with 888sport, Oddschecker, and Colossus Bets to name a few. Based in the UK, Sam also runs Franchise Sports with his brother.